{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:47:12Z","timestamp":1785800832342,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Recent preclinical and clinical data have suggested a potential benefit of photodynamic therapy (PDT) in the treatment of periodontitis. However, there are very limited data from controlled clinical trials evaluating the effect of PDT in the treatment of periodontitis. The aim of this study was to evaluate the clinical and microbiologic effects of the adjunctive use of PDT to non\u2010surgical periodontal treatment.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty\u2010four subjects with chronic periodontitis were randomly treated with scaling and root planing followed by a single episode of PDT (test) or scaling and root planing alone (control). Full\u2010mouth plaque score (FMPS), full\u2010mouth bleeding score (FMBS), probing depth (PD), gingival recession, and clinical attachment level (CAL) were measured at baseline and 3 and 6 months after therapy. Primary outcome variables were changes in PD and CAL. Microbiologic evaluation of <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> (previously <jats:italic>Actinobacillus actinomycetemcomitans<\/jats:italic>), <jats:italic>Porphyromonas gingivali<\/jats:italic>s, <jats:italic>Prevotella intermedia<\/jats:italic>, <jats:italic>Tannerella forsythia<\/jats:italic> (previously <jats:italic>T. forsythensis<\/jats:italic>), <jats:italic>Treponema denticola<\/jats:italic>, <jats:italic>Parvimonas micra<\/jats:italic> (previously <jats:italic>Peptostreptococcus micros<\/jats:italic> or <jats:italic>Micromonas micros<\/jats:italic>), <jats:italic>Fusobacterium nucleatum<\/jats:italic>, <jats:italic>Campylobacter rectus<\/jats:italic>, <jats:italic>Eubacterium nodatum<\/jats:italic>, <jats:italic>Eikenella corroden<\/jats:italic>s, and <jats:italic>Capnocytophaga<\/jats:italic> spp. was performed at baseline and 3 and 6 months following therapy by using a commercially available polymerase chain reaction test.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> At 3 and 6 months after treatment, there were no statistically significant differences between the groups with regard to CAL, PD, FMPS, or microbiologic changes. At 3 and 6 months, a statistically significantly greater improvement in FMBS was found in the test group.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The additional application of a single episode of PDT to scaling and root planing failed to result in an additional improvement in terms of PD reduction and CAL gain, but it resulted in a significantly higher reduction in bleeding scores compared to scaling and root planing alone.<\/jats:p>","DOI":"10.1902\/jop.2008.070652","type":"journal-article","created":{"date-parts":[[2008,9,4]],"date-time":"2008-09-04T20:03:05Z","timestamp":1220558585000},"page":"1638-1644","source":"Crossref","is-referenced-by-count":187,"title":["Photodynamic Therapy as an Adjunct to Non\u2010Surgical Periodontal Treatment: A Randomized, Controlled Clinical 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