{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:34:20Z","timestamp":1792456460810,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Modifying the balance between resorption and apposition through selectively injuring the cortical plate of the alveolus has been an approach to speed tooth movement and is referred to as periodontally accelerated osteogenic orthodontics. The aim of this study was to investigate the alveolar response to corticotomy as a function of time and proximity to the surgical injury in a rat model.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Maxillary buccal and lingual cortical plates were injured in 36 healthy adult rats adjacent to the upper left first molars. Twenty\u2010four animals were euthanized at 3, 7, or 11 weeks. In one group, the maxillae were removed and stripped of soft tissues, and histomorphometric analysis was performed to study alveolar spongiosa and periodontal ligament (PDL) modeling dynamics. Catabolic activity was analyzed with tartrate\u2010resistant acid phosphatase\u2013positive osteoclasts and preosteoclasts. Anabolic actions were measured using a fluorescent vital bone stain series followed by sacrifice at 30 and 51 days. To further analyze the new bone formation, a separate group of animals were fed with calcein fluorescent stain and processed for non\u2010decalcified fluorescent stain histology.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> At 3 weeks, the surgery group had significantly (<jats:italic>P<\/jats:italic> &lt;0.05) less calcified spongiosa bone surface, greater periodontal ligament surface, higher osteoclast number, and greater lamina dura apposition width. The catabolic activity (osteoclast count) and anabolic activity (apposition rate) were three\u2010fold greater, calcified spongiosa decreased by two\u2010fold, and PDL surface increased by two\u2010fold. Surgical injury to the alveolus that induced a significant increase in tissue turnover by week 3 dissipated to a steady state by postoperative week 11. The impact of the injury was localized to the area immediately adjacent to the decortication injury.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Selective alveolar decortication induced increased turnover of alveolar spongiosa, and the activity was localized; dramatic escalation of demineralization\u2010remineralization dynamics is the likely biologic mechanism underlying rapid tooth movement following selective alveolar decortication.<\/jats:p>","DOI":"10.1902\/jop.2008.080024","type":"journal-article","created":{"date-parts":[[2008,9,4]],"date-time":"2008-09-04T20:03:05Z","timestamp":1220558585000},"page":"1679-1688","source":"Crossref","is-referenced-by-count":174,"title":["Modeling of Trabecular Bone and Lamina Dura Following Selective Alveolar Decortication in Rats"],"prefix":"10.1002","volume":"79","author":[{"given":"Jean\u2010David","family":"Sebaoun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpdogan","family":"Kantarci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto S.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Van Dyke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald J.","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sodo.2004.01.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/22.4.343"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(81)90289-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(84)90163-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0889-5406(88)90077-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-8532(22)02820-8"},{"key":"e_1_2_7_8_1","first-page":"331","article-title":"Rate of mesial translation of mandibular molars using implant\u2010anchored mechanics","volume":"66","author":"Roberts WE","year":"1996","journal-title":"Angle Orthod"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(59)90153-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(59)90051-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(59)90177-X"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0503(75)80022-1"},{"key":"e_1_2_7_13_1","first-page":"7","article-title":"Corticotomy\u2010facilitated orthodontics","volume":"14","author":"Anholm JM","year":"1986","journal-title":"CDA J"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1990.61.4.234"},{"key":"e_1_2_7_15_1","first-page":"216","article-title":"Combined surgical and orthodontic management of anterior open bite using corticotomy","volume":"36","author":"Generson RM","year":"1978","journal-title":"J Oral Surg"},{"key":"e_1_2_7_16_1","unstructured":"SuyaH.Corticotomy in orthodontics. 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