{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:09:00Z","timestamp":1761235740618,"version":"build-2065373602"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Cytokine gene polymorphisms are known to influence the susceptibility and disease course of many chronic disorders. Recently, interleukin (IL)\u20104 gene polymorphisms were associated with aggressive periodontitis. The aim of this study was to test differences in the distribution of the IL\u20104 alleles, genotypes, and haplotypes between patients with chronic periodontitis (CP) and healthy controls in a Czech population.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The association study was conducted using an age\u2010 and smoking status\u2013matched case\u2010control design in patients with CP (n = 194) and healthy controls (n = 158) using the polymerase chain reaction\u2013restriction fragment length polymorphism methods for the \u2212590C\/T, \u221233C\/T, and intron 3 variable number tandem repeat (VNTR) variants of the IL\u20104 gene.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> No significant differences between patients and controls were found in allele and genotype frequencies of all three polymorphisms. Nevertheless, complex analysis revealed significant differences in haplotype frequencies between the groups (<jats:italic>P<\/jats:italic> = 0.005). The haplotype T(\u2212590)\/T(\u221233)\/allele 2 VNTR (70 base pairs)<jats:sub>2<\/jats:sub> of the IL\u20104 gene was significantly more frequent in patients with CP than in controls (17.0% versus 11.0%; odds ratio = 1.85; 95% confidence interval: 1.19 to 2.87).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The three polymorphisms in the IL\u20104 gene act in a cooperative fashion and suggest that the high\u2010production IL\u20104 haplotype was associated with an increased risk for CP in the Czech population.<\/jats:p>","DOI":"10.1902\/jop.2008.080035","type":"journal-article","created":{"date-parts":[[2008,10,3]],"date-time":"2008-10-03T09:21:16Z","timestamp":1223025676000},"page":"1927-1933","source":"Crossref","is-referenced-by-count":36,"title":["The Association of Interleukin\u20104 Haplotypes With Chronic Periodontitis in a Czech Population"],"prefix":"10.1002","volume":"79","author":[{"given":"Lydie Izakovicova","family":"Holla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonin","family":"Fassmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Augustin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Halabala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Znojil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiri","family":"Vanek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"26","article-title":"Is periodontitis genetic? The answer may be Yes!","volume":"49","author":"Kornman KS","year":"2000","journal-title":"J Mass Dent Soc"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411980090030101"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(92)90056-I"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1993.tb02108.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00192.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1983.tb00373.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1995.tb05562.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00194.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.4049\/jimmunol.148.6.1812","article-title":"IL\u20104 enhances programmed cell death (apoptosis) in stimulated human monocytes","volume":"148","author":"Mangan DF","year":"1992","journal-title":"J Immunol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8178175"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1995.tb00428.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.4.12tac-14"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/19.13.3763"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(03)00131-7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(97)00058-1"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363830"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028005483.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00317.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02976867"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00492.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2003.11.004"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01086.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350701644040"},{"key":"e_1_2_7_25_1","first-page":"281","article-title":"Development of the World Health Organization (WHO) community periodontal index of treatment needs (CPITN)","volume":"32","author":"Ainamo J","year":"1982","journal-title":"Int Dent J"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.11.844"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_28_1","first-page":"1005","article-title":"X\u2010ray diagnosis (in German)","volume":"65","author":"M\u00fchlemann HR","year":"1955","journal-title":"Schweiz Mschr Zahnheilk"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.2.156"},{"key":"e_1_2_7_30_1","first-page":"9","volume-title":"Molecular Cloning: A Laboratory Manual","author":"Sambrook J","year":"1989"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.6.1832"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/120.3.849"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1086\/319501"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1086\/379378"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.4.5.547"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.56.082103.104540"},{"key":"e_1_2_7_37_1","first-page":"131","article-title":"Changes of circulating IFN\u2010gamma, IL\u20104 in patients with chronic periodontitis before and after periodontal initial therapy (in Chinese)","volume":"14","author":"Zong M","year":"2005","journal-title":"Shanghai Kou Qiang Yi Xue"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.3.9812024"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.107926"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.10.1126"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10394"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/096293500411587"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2003.02287.x"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2008.080035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:51:58Z","timestamp":1760874718000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2008.080035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1902\/jop.2008.080035"],"URL":"https:\/\/doi.org\/10.1902\/jop.2008.080035","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}