{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T12:47:20Z","timestamp":1775911640018,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> This study aimed to compare the effectiveness of non\u2010surgical periodontal treatment in improving periodontal status and reducing gingival crevicular fluid (GCF) levels of interleukin (IL)\u20101\u03b2 and IL\u201018, elastase activity, and matrix metalloproteinase (MMP)\u2010\u20108 and \u2010\u20109 in periodontitis patients with and without type 2 diabetes mellitus (T2DM).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty\u2010three patients with T2DM (diabetes group) and 26 systemically healthy subjects (control group) with chronic periodontitis participated in this study. The clinical examination included visible plaque index, gingival bleeding index, probing depth, clinical attachment level, and bleeding on probing. GCF samples were collected from five or six deep sites to evaluate the levels of IL\u20101\u03b2 and \u221218, elastase, and MMP\u20108 and \u22129. Shallow sites were analyzed for IL\u20101\u03b2 and elastase. The glycemic control was analyzed by the concentration of glycated hemoglobin (HbA1c). The subjects received non\u2010surgical periodontal treatment and were reexamined 90 days later.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> All clinical parameters showed a significant improvement after treatment, which was accompanied by a significant reduction in IL\u20101\u03b2, elastase activity, and MMP\u20108 and \u22129 levels in deep sites. The shallow sites also showed significant reductions in IL\u20101\u03b2 and elastase activity levels. Treatment did not significantly reduce HbA1c concentrations in patients with T2DM.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Non\u2010surgical periodontal treatment was effective in reducing the levels of IL\u20101\u03b2, elastase activity, and MMP\u20108 and \u22129 in GCF from diabetes and control groups. Patients with T2DM showed less reduction only in elastase activity in shallow sites compared to controls. This reduction was associated with improvement of the clinical periodontal status.<\/jats:p>","DOI":"10.1902\/jop.2008.080132","type":"journal-article","created":{"date-parts":[[2008,11,3]],"date-time":"2008-11-03T21:48:55Z","timestamp":1225748935000},"page":"2143-2150","source":"Crossref","is-referenced-by-count":52,"title":["The Short\u2010Term Effectiveness of Non\u2010Surgical Treatment in Reducing Levels of Interleukin\u20101\u03b2 and Proteases in Gingival Crevicular Fluid From Patients With Type 2 Diabetes Mellitus and Chronic Periodontitis"],"prefix":"10.1002","volume":"79","author":[{"given":"Fernanda O.B.","family":"Correa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos 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