{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:55:09Z","timestamp":1791226509732,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"8S","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01\u2010DE14961"],"award-info":[{"award-number":["U01\u2010DE14961"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p>Periodontal diseases are initiated by Gram\u2010negative tooth\u2010associated microbial biofilms that elicit a host response, with resultant osseous and soft tissue destruction. In response to endotoxins derived from periodontal pathogens, several osteoclast\u2010related mediators target the destruction of alveolar bone and supporting connective tissues. Major drivers of this aggressive tissue destruction are matrix metalloproteinases (MMPs), cathepsins, and other osteoclast\u2010derived enzymes. This article focuses on the downstream factors of the osteoclast responsible for the degradation of bone and soft tissues around teeth and oral implants. Furthermore, therapeutic approaches that target MMP\u20102, \u22128, and \u22129 inhibition, such as MMP inhibitors, chemically modified tetracyclines, and subantimicrobial formulations of tetracycline analogues, are discussed. The use of rapid, chair\u2010side tests of MMP activity, in particular for MMP\u20108 and bone collagen fragments, show strong potential as non\u2010invasive measures of tissue health or disease. In addition, studies using other agents for the preservation of bone mass, such as bisphosphonates that inhibit osteoclast recruitment, are highlighted. The application of these bone\u2010preservation strategies to periodontal management and treatment are discussed in the context of high\u2010risk patients susceptible to disease reactivation or disease complications.<\/jats:p>","DOI":"10.1902\/jop.2008.080174","type":"journal-article","created":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T13:25:03Z","timestamp":1217597103000},"page":"1592-1600","source":"Crossref","is-referenced-by-count":126,"title":["Host\u2010Response Therapeutics for Periodontal Diseases"],"prefix":"10.1002","volume":"79","author":[{"given":"William V.","family":"Giannobile","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1384.028"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.290103.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.07.024"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986707781745604"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2007.146"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2007.07.001"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000312"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2007.10.024"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2228"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890600800103"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050193"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1384.004"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607254104"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.00663.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00166.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500201"},{"key":"e_1_2_8_18_1","first-page":"80","article-title":"Host modulation with tetracyclines and their chemically modified analogues","volume":"2","author":"Golub LM","year":"1992","journal-title":"Curr Opin Dent"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199002083220606"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032906"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb07693.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/08959374980120011501"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.4.521"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.12"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070375"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.3.441"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01115.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01114.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070623"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161207781039706"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.7.813"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2007.06.005"},{"key":"e_1_2_8_33_1","first-page":"365","volume-title":"Alveolar bone loss and osteoporosis: Evidence for a common mode of therapy using the bisphosphonate alendronate","author":"Jeffcoat MK","year":"1996"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.2.204"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323000102900413"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.7.1113"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060239"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00842.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.0707onj"},{"key":"e_1_2_8_40_1","unstructured":"Expert Panel Recommendation for the Prevention Diagnosis and Treatment of Osteonecrosis of the Jaw. Available at:http:\/\/www.fda.gov\/OHRMS\/DOCKETS\/AC\/05\/briefing\/2005\u20104095B2_02_12\u2010Novartis\u2010Zometa\u2010App\u201011.pdf. Accessed January 23 2008."},{"key":"e_1_2_8_41_1","unstructured":"American Academy of Periodontology. AAP statement on bisphosphonates.http:\/\/www.perio.org\/resources\u2010products\/bisphosphonates.htm. Published 2005. 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