{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:18:44Z","timestamp":1791134324034,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Periodontal disease is infectious in nature and leads to an inflammatory response. It arises from the accumulation of subgingival bacterial plaque and leads to the loss of attachment, increased probing depth, and bone loss. It is one of the world's most prevalent chronic diseases. In this study we developed and studied metronidazole\u2010loaded 50\/50 poly(DL\u2010lactide\u2010co\u2010glycolide) (PDLGA), 75\/25 PDLGA, and poly(DL\u2010lactic acid) (PDLLA) films. These films are designed to be inserted into the periodontal pocket and treat infections with controlled\u2010release metronidazole for \u22651 month.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The structured films were prepared using the solution\u2010casting technique. Concentrated solutions and high solvent\u2010evaporation rates were used to get most of the drug located in the bulk, i.e., in whole film's volume. The effects of copolymer composition and drug content on the release profile, cell growth, and bacterial inhibition were investigated.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The PDLLA and 75\/25 PDLGA films generally exhibited a low\u2010 or medium\u2010burst release followed by a moderate release at an approximately constant rate, whereas the 50\/50 PDLGA films exhibited a biphasic release profile. The drug released from films loaded with 10% weight\/weight metronidazole resulted in a significant decrease in bacterial viability within several days. When exposed to human gingival fibroblasts in cell culture conditions, these films maintained their normal fibroblastic features.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> This study enabled the understanding of metronidazole\u2010release kinetics from bioabsorbable polymeric films. The developed systems demonstrated good biocompatibility and the ability to inhibit <jats:italic>Bacteroides fragilis<\/jats:italic> growth; therefore, they may be useful in the treatment of periodontal diseases.<\/jats:p>","DOI":"10.1902\/jop.2009.080216","type":"journal-article","created":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T10:22:40Z","timestamp":1233570160000},"page":"330-337","source":"Crossref","is-referenced-by-count":31,"title":["Metronidazole\u2010Loaded Bioabsorbable Films as Local Antibacterial Treatment of Infected Periodontal 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