{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T15:49:36Z","timestamp":1770133776681,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Cytokines and cytokine inhibitors have been associated with many immunoinflammatory diseases. In the present study, we examined whether peripheral blood mononuclear cell (PBMC) gene expression mirrors the corresponding plasma levels of clinically important pro\u2010 and anti\u2010inflammatory cytokines and cytokine receptors in patients with periodontitis and patients with arthritis representing two examples of chronic inflammatory diseases, such as periodontitis and arthritis. To identify possible disease\u2010specific characteristics of subjects with periodontitis relative to subjects with chronic inflammation in general, patients with arthritis (juvenile idiopathic arthritis [JIA] and rheumatoid arthritis [RA]) were included.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The study population consisted of white adults &lt;35 years of age diagnosed with localized aggressive periodontitis (LAgP; n = 18), generalized aggressive periodontitis (GAgP; n = 27), JIA (n = 10), and RA (n = 23) and healthy controls (n = 25). PBMC transcripts of interleukin (IL) 1 alpha (<jats:italic>IL1A<\/jats:italic>), IL 1 beta (<jats:italic>IL1B<\/jats:italic>), IL 1 receptor antagonist (<jats:italic>IL1RN<\/jats:italic>), <jats:italic>IL6<\/jats:italic>, <jats:italic>IL10<\/jats:italic>, tumor necrosis factor alpha (<jats:italic>TNFA<\/jats:italic>), TNF alpha receptor I (<jats:italic>TNFRI<\/jats:italic>), and <jats:italic>TNFRII<\/jats:italic> were measured using real\u2010time reverse transcription\u2010polymerase chain reaction and compared to the corresponding plasma protein levels measured by enzyme\u2010linked immunosorbent assay and a multiplex antibody bead assay.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Compared to controls, soluble (s) TNF\u2010RII levels were significantly elevated in patients with GAgP (<jats:italic>P<\/jats:italic> = 0.001) or JIA (<jats:italic>P<\/jats:italic> = 0.002), and PBMC <jats:italic>TNFA<\/jats:italic> transcript levels were lower in patients with JIA (<jats:italic>P<\/jats:italic> = 0.001). A negative correlation was found between <jats:italic>IL6<\/jats:italic> expression and IL\u20106 plasma levels in patients with JIA versus controls, and a positive correlation\/association was found between <jats:italic>TNFRI<\/jats:italic> expression and sTNF\u2010RI plasma levels in patients with LAgP and RA.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The study demonstrated only a few changes in the PBMC expression of various cytokine and cytokine inhibitor genes in aggressive periodontitis and chronic arthritis compared to controls. There were a few similarities among disease groups, and no direct and simple correlation between cellular transcripts and proteins was found.<\/jats:p>","DOI":"10.1902\/jop.2009.080347","type":"journal-article","created":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T10:22:40Z","timestamp":1233570160000},"page":"282-289","source":"Crossref","is-referenced-by-count":18,"title":["Aggressive Periodontitis and Chronic Arthritis: Blood Mononuclear Cell Gene Expression and Plasma Protein Levels of Cytokines and Cytokine Inhibitors"],"prefix":"10.1002","volume":"80","author":[{"given":"Lars 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