{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:18:43Z","timestamp":1791134323576,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    The purpose of this study was to evaluate the adjunctive clinical, microbiologic, and immunologic effects of the systemic administration of amoxicillin and metronidazole in the full\u2010mouth ultrasonic debridement of patients with severe chronic periodontitis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Twenty\u2010five patients presenting at least eight teeth with probing depth (PD) \u22655 mm and bleeding on probing (BOP) were selected and randomly assigned to full\u2010mouth ultrasonic debridement + placebo (control group) or full\u2010mouth ultrasonic debridement + amoxicillin and metronidazole (test group). The clinical outcomes evaluated were visible plaque index, BOP, position of the gingival margin, relative attachment level (RAL), and PD. Real\u2010time polymerase chain reaction (PCR) was used for quantitative analysis of\n                    <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>\n                    (previously\n                    <jats:italic>Actinobacillus actinomycetemcomitans<\/jats:italic>\n                    ),\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    , and\n                    <jats:italic>Tannerella forsythia<\/jats:italic>\n                    (previously\n                    <jats:italic>T. forsythensis<\/jats:italic>\n                    ). The enzyme\u2010linked immunosorbent assay (ELISA) technique permitted the detection of prostaglandin E\n                    <jats:sub>2,<\/jats:sub>\n                    interleukin\u20101\u03b2, and interferon\u2010gamma levels in gingival crevicular fluid. All parameters were evaluated at baseline and at 3 and 6 months post\u2010treatment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    At 6 months, the test treatment resulted in lower BOP and an additional reduction (0.83 mm) in PD (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). Data also showed RAL gain \u22652 mm at 43.52% of sites in control patients compared to 58.03% of sites in test patients (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). However, both groups had similar mean RAL gain (1.68 and 1.88 mm for the control and test groups, respectively). Real\u2010time PCR and ELISA failed to identify significant differences between the groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Both treatments resulted in significant clinical improvements; however, there was a slight, but significantly greater, improvement in BOP and the percentage of sites with PD \u22655 mm exhibiting RAL gain \u22652 mm in the test group. Nevertheless, no improvement in the microbiologic or immunologic outcome was observed with the adjunctive use of systemic amoxicillin and metronidazole.\n                  <\/jats:p>","DOI":"10.1902\/jop.2009.080403","type":"journal-article","created":{"date-parts":[[2009,8,5]],"date-time":"2009-08-05T10:22:45Z","timestamp":1249467765000},"page":"1254-1264","source":"Crossref","is-referenced-by-count":59,"title":["Full\u2010Mouth Ultrasonic Debridement Associated With Amoxicillin and Metronidazole in the Treatment of Severe Chronic Periodontitis"],"prefix":"10.1002","volume":"80","author":[{"given":"\u00c9rica Del Peloso","family":"Ribeiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Bittencourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iriana Carla 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