{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:10:44Z","timestamp":1790982644964,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Recently, there has been an increasing in the impact of oral health on atherosclerosis and subsequent cardiovascular disease. The aim of this study is to investigate the association between chronic periodontitis and cardiovascular risk markers.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Forty patients with periodontitis and 40 healthy gender\u2010, body mass index\u2013, and age\u2010matched individuals were compared by measuring total cholesterol, high\u2010density lipoprotein, low\u2010density lipoprotein, triglycerides, levels of cytokines, antibodies against oxidized low\u2010density lipoprotein, thiobarbituric acid reactive substances, total and differential white blood cell counts, and the non\u2010linear index of refraction.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The levels of triglycerides and high\u2010density lipoprotein in periodontitis patients were significantly higher and lower, respectively (<jats:italic>P<\/jats:italic> = 0.002 and <jats:italic>P<\/jats:italic> = 0.0126), compared to controls. Total cholesterol, low\u2010density lipoprotein, and lipid peroxide levels were the same in both groups (<jats:italic>P<\/jats:italic> = 0.2943, <jats:italic>P<\/jats:italic> = 0.1284, and <jats:italic>P<\/jats:italic> = 0.067, respectively). Interleukin (IL)\u20106 and \u22128, antibodies against oxidized low\u2010density lipoprotein, and leukocyte and neutrophil counts were significantly higher in periodontitis patients (<jats:italic>P<\/jats:italic> &lt;0.05). The value of the non\u2010linear index of refraction of low\u2010density lipoprotein solutions was higher in the controls (<jats:italic>P<\/jats:italic> = 0.015) compared to individuals with periodontitis.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Our results confirmed and further strengthened the suggested association between coronary artery disease and periodontitis.<\/jats:p>","DOI":"10.1902\/jop.2009.080431","type":"journal-article","created":{"date-parts":[[2009,3,2]],"date-time":"2009-03-02T08:44:02Z","timestamp":1235983442000},"page":"378-388","source":"Crossref","is-referenced-by-count":88,"title":["Cardiovascular Disease Parameters in Periodontitis"],"prefix":"10.1002","volume":"80","author":[{"given":"Andr\u00e9a M.","family":"Monteiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria 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