{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:45:11Z","timestamp":1791189911514,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Recent epidemiologic studies suggest that inflammation is the link between periodontal diseases and cardiovascular complications. This study aimed to evaluate the effects of non\u2010surgical periodontal treatment on plasma levels of inflammatory markers (interleukin [IL]\u20106, C\u2010reactive protein [CRP], and fibrinogen) in patients with severe periodontitis and refractory arterial hypertension.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty\u2010two patients were examined and randomly divided into two groups. The test group was composed of 11 patients (mean age, 48.9 \u00b1 3.9 years) who received periodontal treatment, whereas the control group had 11 patients (mean age, 49.7 \u00b1 6.0 years) whose treatment was delayed for 3 months. Demographic and clinical periodontal data were collected, and blood tests were performed to measure the levels of IL\u20106, CRP, and fibrinogen at baseline and 3 months later.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The clinical results showed that the mean percentages of sites with bleeding on probing, probing depth (PD) 4 to 5 mm, PD \u22656 mm, clinical attachment loss (CAL) 4 to 5 mm, and CAL \u22656 mm were significantly reduced in the test group 3 months after periodontal treatment. There were no significant differences between the data at baseline and 3 months in the control group. Periodontal treatment significantly reduced the blood levels of fibrinogen, CRP, and IL\u20106 in the test group.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Non\u2010surgical periodontal therapy was effective in improving periodontal clinical data and in reducing the plasma levels of IL\u20106, CRP, and fibrinogen in hypertensive patients with severe periodontitis.<\/jats:p>","DOI":"10.1902\/jop.2009.080471","type":"journal-article","created":{"date-parts":[[2009,4,30]],"date-time":"2009-04-30T12:45:43Z","timestamp":1241095543000},"page":"786-791","source":"Crossref","is-referenced-by-count":151,"title":["Periodontal Therapy Reduces Plasma Levels of Interleukin\u20106, C\u2010Reactive Protein, and Fibrinogen in Patients With Severe Periodontitis and Refractory Arterial Hypertension"],"prefix":"10.1002","volume":"80","author":[{"given":"F\u00e1bio","family":"Vidal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Marcelo 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