{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:10:45Z","timestamp":1789495845388,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The primary aims of this two\u2010part prospective study were: 1) to compare the safety and efficacy of beta\u2010tricalcium phosphate (\u03b2\u2010TCP) + 0.3 mg\/ml recombinant human platelet\u2010derived growth factor\u2010BB (rhPDGF\u2010BB) with a bioabsorbable collagen wound\u2010healing dressing and a coronally advanced flap (CAF) to a subepithelial connective tissue graft (CTG) in combination with a CAF in subjects with gingival recession defects using a randomized, controlled, split\u2010mouth design; and 2) to compare, through histologic and microcomputed tomography (micro\u2010CT) examination, the periodontal regenerative potential of these two therapies in surgically created gingival recession defects in restoring missing cementum, periodontal ligament (PDL), and supporting alveolar bone.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> In the randomized controlled trial (RCT), 30 patients with Miller Class II buccal gingival recession, \u22653 mm deep and \u22653 mm wide in contralateral quadrants of the same jaw were treated and followed for 6 months. Using a split\u2010mouth design with similar bilateral recession defects, test sites were treated with 0.3 mg\/ml rhPDGF\u2010BB + \u03b2\u2010TCP + bioabsorbable collagen wound\u2010healing dressing; contralateral control sites were treated with a CTG, each in combination with a CAF. In the histologic\/micro\u2010CT study segment, recession defects were created in six teeth, each requiring extraction for orthodontic therapy. These defects were created with a recession depth \u22653 mm, the osseous crest 2 to 3 mm apical to the gingival margin, and with 2 to 3 mm of keratinized tissue. The defects were treated with a CTG (control) or rhPDGF\u2010BB + \u03b2\u2010TCP + wound\u2010healing dressing (test), plus CAF. Nine months after surgical correction, en bloc resections were obtained and examined histologically and with micro\u2010CT.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> In the RCT, test and control treatments demonstrated clinically significant improvements from baseline through month 6. Statistically significant results favoring the CTG were found in recession depth reduction (\u22122.9 + 0.5 mm, test; \u22123.3 + 0.6 mm, control; <jats:italic>P<\/jats:italic> = 0.009), root coverage (90.8%, test; 98.6%, control; <jats:italic>P<\/jats:italic> = 0.013), and \u22123.9 \u00b1 0.7 mm, control, \u22123.3 \u00b1 1.3 mm, test, recession width reduction (<jats:italic>P<\/jats:italic> = 0.035), whereas mid\u2010buccal probing depth (PD) and PD reduction (PDR) reduction favored the test group (1.4 \u00b1 0.4 mm, test; 1.8 \u00b1 0.1 mm, control; <jats:italic>P<\/jats:italic> &lt; 0.001 PD and \u22120.0 mm test; +0.4 mm control PDR). For all other parameters, the two treatments were statistically equivalent, including increases in keratinized tissue, esthetic results, and subject satisfaction. In the histologic\/micro\u2010CT portion, all four sites treated with rhPDGF\u2010BB + \u03b2\u2010TCP showed evidence of regeneration of cementum, PDL with inserting connective tissue fibers, and supporting alveolar bone, whereas neither CTG\u2010treated site exhibited any signs of periodontal regeneration.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> CTG and rhPDGF\u2010BB + \u03b2\u2010TCP + wound\u2010healing dressing are effective treatment modalities for clinically correcting gingival recession defects. In addition, the current study demonstrated that regeneration of the periodontium in gingival recession defects was possible through a growth factor\u2013mediated approach.<\/jats:p>","DOI":"10.1902\/jop.2009.080502","type":"journal-article","created":{"date-parts":[[2009,3,31]],"date-time":"2009-03-31T09:42:01Z","timestamp":1238492521000},"page":"550-564","source":"Crossref","is-referenced-by-count":74,"title":["Growth Factor\u2013Mediated Treatment of Recession Defects: A Randomized Controlled Trial and Histologic and Microcomputed Tomography Examination"],"prefix":"10.1002","volume":"80","author":[{"given":"Michael K.","family":"McGuire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Todd","family":"Scheyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schupbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1999.tb00152.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s3.11.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.303"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.9.1054"},{"key":"e_1_2_7_6_1","first-page":"19","article-title":"Long\u2010term results of root coverage with connective tissue in the envelope technique: A report of 20 cases","volume":"28","author":"Rossberg M","year":"2008","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_7_1","first-page":"439","article-title":"Successful root coverage: A human histologic evaluation of a case","volume":"19","author":"Harris RJ","year":"1999","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028007657.x"},{"key":"e_1_2_7_9_1","first-page":"225","article-title":"Histology of a human biopsy section following the placement of a subepithelial connective tissue graft","volume":"20","author":"Bruno JF","year":"2000","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.7.813"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.11.1607"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.2.178"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1989.tb02334.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.6.515"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.12.2205"},{"key":"e_1_2_7_16_1","first-page":"213","article-title":"Periodontal regeneration in human Class II furcations using purified recombinant human platelet\u2010derived growth factor\u2010BB (rhPDGF\u2010BB) with bone allograft","volume":"23","author":"Camelo M","year":"2003","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.9.1282"},{"key":"e_1_2_7_18_1","first-page":"171","article-title":"Human histologic and clinical evaluation of recombinant human platelet\u2010derived growth factor and beta\u2010tricalcium phosphate for the treatment of periodontal intraosseous defects","volume":"28","author":"Ridgway HK","year":"2008","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_19_1","first-page":"127","article-title":"Comparison of recombinant human platelet\u2010derived growth factor\u2010BB plus beta tricalcium phosphate and a collagen membrane to subepithelial connective tissue grafting for the treatment of recession defects: A case series","volume":"26","author":"McGuire MK","year":"2006","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_20_1","first-page":"8","article-title":"A classification of marginal tissue recession","volume":"5","author":"Miller PD","year":"1985","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_21_1","first-page":"12","article-title":"The effect of Listerine antiseptic on reduction of existing plaque and gingivitis","volume":"5","author":"Lamster IB","year":"1983","journal-title":"Clin Prev Dent"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2005.07.030"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2005.11.369"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504705102"},{"key":"e_1_2_7_25_1","first-page":"365","article-title":"Three\u2010dimensional micro\u2010computed tomographic evaluation of periodontal regeneration: A human report of intrabony defects treated with Bio\u2010Oss collagen","volume":"25","author":"Nevins ML","year":"2005","journal-title":"Int J Periodontics Restorative Dent"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2009.080502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:19:31Z","timestamp":1760865571000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2009.080502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1902\/jop.2009.080502"],"URL":"https:\/\/doi.org\/10.1902\/jop.2009.080502","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}