{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:35:03Z","timestamp":1789940103781,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Extraction of deep\u2010impacted mandibular third molars may lead to periodontal defects at the distal surface of the adjacent second molar. The purpose of this study was to compare the ability of three regenerative approaches to prevent third molar extraction\u2010related periodontal defects.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Forty\u2010five patients with bilateral osseous or soft tissue\u2013impacted lower third molars were selected to participate in the study. Inclusion criteria were the presence of a pocket that was located distally to the mandibular second molar with a probing depth (PD) \u22657 mm and with a probing clinical attachment level (CAL) \u22656 mm. Ninety third molar impactions were used and were randomly assigned to three equal treatment groups (30 each): bovine porous bone mineral (BPBM) alone, BPBM plus collagen membrane (CM), and an untreated control group. Clinical and radiographic measurements were recorded at 3, 6, 9, 12, 18, 24, 36, 48, 60, and 72 months after the surgery.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> BPBM or BPBM + CM resulted in a significant reduction in PD and gain in CAL compared to the control group at all time points. BPBM + CM had the best outcome for the prevention of a second\u2010molar periodontal defect.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The application of BPBM, with or without a collagen membrane, can be a viable and stable treatment to alleviate the periodontal defects that are often associated with impacted mandibular third molar extractions.<\/jats:p>","DOI":"10.1902\/jop.2009.080503","type":"journal-article","created":{"date-parts":[[2009,3,2]],"date-time":"2009-03-02T08:44:02Z","timestamp":1235983442000},"page":"389-396","source":"Crossref","is-referenced-by-count":40,"title":["Prevention of Mandibular Third Molar Extraction\u2010Associated Periodontal Defects: A Comparative Study"],"prefix":"10.1002","volume":"80","author":[{"given":"Gilberto","family":"Sammartino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Tia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Bucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hom\u2010Lay","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1962.33.3.209"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(85)80007-7"},{"key":"e_1_2_7_4_1","first-page":"185","article-title":"Crevicular depth of the second molar in impacted third molar surgery","volume":"21","author":"Szmyd L","year":"1963","journal-title":"J Oral Surg Anaesth Hosp Dent Surv"},{"key":"e_1_2_7_5_1","first-page":"297","article-title":"The periodontal implications of flap design in lower third molar extractions","volume":"20","author":"Groves BJ","year":"1970","journal-title":"Dent Pract Dent Rec"},{"key":"e_1_2_7_6_1","first-page":"25","article-title":"The influence of third molars on periodontal health","volume":"53","author":"Labelle RE","year":"1969","journal-title":"Minneap Dist Dent J"},{"key":"e_1_2_7_7_1","first-page":"51","article-title":"Clinical and radiographic evaluation of the effects of guided tissue regeneration using resorbable membranes after extraction of impacted mandibular third molars","volume":"27","author":"Aimetti M","year":"2007","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00213.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1563\/0.824.1"},{"key":"e_1_2_7_10_1","first-page":"614","article-title":"Ridge preservation and augmentation using regenerative materials to enhance implant predictability and esthetics","volume":"28","author":"Keith JD","year":"2007","journal-title":"Compend Contin Educ Dent"},{"key":"e_1_2_7_11_1","first-page":"321","article-title":"Clinical, radiographic and histologic evaluation of human periodontal defects treated with Bio\u2010Oss and Bio\u2010Gide","volume":"18","author":"Camelo M","year":"1998","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_12_1","first-page":"361","article-title":"GBR using bovine bone matrix and resorbable and nonresorbable membranes. Part 1: Histologic results","volume":"23","author":"Fugazzotto PA","year":"2003","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_13_1","first-page":"599","article-title":"GBR using bovine bone matrix and resorbable and nonresorbable membranes. Part 2: Clinical results","volume":"23","author":"Fugazzotto PA","year":"2003","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1990.61.6.319"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2002.01001.x"},{"key":"e_1_2_7_16_1","first-page":"109","article-title":"Periodontal regeneration with an autogenous bone\u2010Bio\u2010Oss composite graft and a Bio\u2010Gide membrane","volume":"21","author":"Camelo M","year":"2001","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.10.838"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.1.38"},{"key":"e_1_2_7_19_1","first-page":"195","article-title":"Gingival sulcus index. A leading symptom in initial gingivitis","volume":"42","author":"Muhleman H","year":"1971","journal-title":"Helv Odontol Acta"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1991.tb01117.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(05)80077-3"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027005325.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027005333.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.02.010"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.4.423"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.01099.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01138.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-005-0002-7"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2009.080503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:28:34Z","timestamp":1760866114000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2009.080503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1902\/jop.2009.080503"],"URL":"https:\/\/doi.org\/10.1902\/jop.2009.080503","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}