{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:33:34Z","timestamp":1787762014205,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["05\/02561\u20103"],"award-info":[{"award-number":["05\/02561\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["06\/04604\u20104"],"award-info":[{"award-number":["06\/04604\u20104"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of the present case series was to evaluate the effects of a surgical anti\u2010infective mechanical therapy for peri\u2010implantitis on clinical parameters and tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) levels at 12 months post\u2010therapy.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Ten patients with peri\u2010implantitis were treated with open surgical debridement, abrasive sodium carbonate air\u2010powder, and resin curets. Clinical parameters were recorded before and 3 and 12 months after therapy. At these time points, the total amounts of TNF\u2010\u03b1 in the peri\u2010implant crevicular fluid were measured by enzyme\u2010linked immunosorbent assay.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> At 3 and 12 months, the anti\u2010infective therapy resulted in significant improvements in all clinical parameters (<jats:italic>P<\/jats:italic> &lt;0.05). Moreover, the total amount of TNF\u2010\u03b1 was significantly reduced at 3 and 12 months after therapy compared to baseline (<jats:italic>P<\/jats:italic> &lt;0.05), paralleling the changes in mean probing depth and bleeding on probing.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The anti\u2010infective mechanical therapy reduced the crevicular levels of TNF\u2010\u03b1 in sites affected by peri\u2010implantitis over a period of 12 months, and this phenomenon was associated with improvements in clinical parameters.<\/jats:p>","DOI":"10.1902\/jop.2009.080521","type":"journal-article","created":{"date-parts":[[2009,3,31]],"date-time":"2009-03-31T09:42:01Z","timestamp":1238492521000},"page":"693-699","source":"Crossref","is-referenced-by-count":23,"title":["Tumor Necrosis Factor\u2010Alpha Levels After Surgical Anti\u2010Infective Mechanical Therapy for Peri\u2010Implantitis: A 12\u2010Month Follow\u2010Up"],"prefix":"10.1002","volume":"80","author":[{"given":"Adriana 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