{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:37:55Z","timestamp":1789954675965,"version":"4.0.1"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Cathelicidin LL\u201037, an antimicrobial peptide, is part of the host innate immune response in the oral cavity. Interleukin (IL)\u201018, a proinflammatory cytokine, could play a role in the progression of the inflammatory response. The aim of the present study was to determine the levels of cathelicidin LL\u201037 and IL\u201018 in the gingival crevicular fluid (GCF) of patients with gingivitis and chronic periodontitis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Fifty\u2010nine subjects were included in the present study. Probing depth (PD), clinical attachment level (CAL), plaque index (PI), bleeding on probing, and papilla bleeding index (PBI) were assessed in patients with chronic periodontitis or gingivitis and in healthy controls. GCF levels of cathelicidin LL\u201037 and IL\u201018 were analyzed by enzyme\u2010linked immunosorbent assay.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> GCF levels of cathelicidin LL\u201037 were significantly elevated in patients with chronic periodontitis compared to the other groups (<jats:italic>P<\/jats:italic> &lt;0.05). No significant difference was found in the total amount of GCF IL\u201018 among the study groups (<jats:italic>P<\/jats:italic> &gt;0.05). Spearman correlation analysis revealed a positive relationship between levels of GCF cathelicidin LL\u201037 and PD, CAL, PI, and PBI at the sampled sites (<jats:italic>P<\/jats:italic> &lt;0.01), whereas no correlation was found between the total amount of GCF IL\u201018 and clinical periodontal parameters at the sampled sites (<jats:italic>P<\/jats:italic> &gt;0.05).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Elevated levels of GCF cathelicidin LL\u201037 in chronic periodontitis suggest that it may play a role in the host innate immune response during periodontal inflammation.<\/jats:p>","DOI":"10.1902\/jop.2009.080532","type":"journal-article","created":{"date-parts":[[2009,6,2]],"date-time":"2009-06-02T08:48:52Z","timestamp":1243932532000},"page":"969-976","source":"Crossref","is-referenced-by-count":90,"title":["Gingival Crevicular Fluid Levels of Cathelicidin LL\u201037 and Interleukin\u201018 in Patients With Chronic 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