{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:18:43Z","timestamp":1791134323211,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    It has been suggested that scaling and root planing of all pockets within a few hours and chlorhexidine treatments (full\u2010mouth disinfection) may reduce the need for supplementary therapies. The aim of this study was to evaluate the clinical benefit of amoxicillin and metronidazole administered immediately after completion of full\u2010mouth periodontal debridement in patients with chronic periodontitis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    This was a single\u2010center, double\u2010masked, placebo\u2010controlled, randomized longitudinal study of 6 months' duration. Fifty\u2010one patients received full\u2010mouth periodontal debridement, performed within 48 hours. Twenty\u2010five subjects received metronidazole, 500 mg, and amoxicillin, 375 mg, three times a day for 7 days; 26 subjects received a placebo.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : Forty\u2010seven patients could be followed up to month 6. No differences in clinical parameters were noted before treatment. The overall mean probing depth decreased from 4.3 \u00b1 0.4 mm to 3.0 \u00b1 0.2 mm in the test group and from 4.4 \u00b1 0.4 mm to 3.1 \u00b1 0.3 mm in the control group (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.05, difference between groups). More importantly, test subjects had a significantly lower mean number of persisting pockets &gt;4 mm and bleeding on probing that required further treatment (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.005): 6 months after full\u2010mouth debridement plus antibiotics, only 0.4 \u00b1 0.8 persisting pockets were still present, whereas 3.0 \u00b1 4.3 persisting pockets were still present in the control group. The protective risk of the antibiotics for having more than one pocket deeper than 4 mm and bleeding on probing per subject after 6 months was 8.85.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Systemic metronidazole and amoxicillin significantly improved the 6\u2010month clinical outcomes of full\u2010mouth non\u2010surgical periodontal debridement, thus significantly reducing the need for additional therapy.\n                  <\/jats:p>","DOI":"10.1902\/jop.2009.080540","type":"journal-article","created":{"date-parts":[[2009,3,2]],"date-time":"2009-03-02T08:44:02Z","timestamp":1235983442000},"page":"364-371","source":"Crossref","is-referenced-by-count":145,"title":["Amoxicillin and Metronidazole as an Adjunct to Full\u2010Mouth Scaling and Root Planing of Chronic Periodontitis"],"prefix":"10.1002","volume":"80","author":[{"given":"Norbert","family":"Cionca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Giannopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Ugolotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mombelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s3.3.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345950740080501"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.6.646"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00890.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050154"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00775.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6979.2004.00461.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00776.x"},{"key":"e_1_2_7_10_1","first-page":"CD004622","article-title":"Full\u2010mouth 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