{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T09:43:21Z","timestamp":1778233401939,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Previous studies showed that non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs) have significant benefits in the control of pain after periodontal surgery. Acetaminophen (centrally acting NSAID) is believed to provide less analgesic efficacy than ibuprofen (centrally and peripherally acting NSAID). This study compared an alternative combination of acetaminophen, 500 mg, with caffeine, 30 mg, to ibuprofen, 400 mg, in pain management after periodontal surgeries.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A prospective, randomized, double\u2010masked crossover clinical trial was conducted on 15 patients. Open flap debridement was performed on two quadrants with a 3\u2010week interval in between. Each quadrant was randomly assigned to acetaminophen, 500 mg, with caffeine, 30 mg, or ibuprofen, 400 mg, immediately after surgery and 8 hours after the first dose. Postoperative pain was assessed during the first 8 hours and on the following day using the 101\u2010point numeric rate scale (NRS\u2010101) and the four\u2010point verbal rating scale (VRS\u20104).<\/jats:p><jats:p><jats:bold>Results<\/jats:bold>: Using the NRS\u2010101, the acetaminophen\u2010caffeine group showed statistically significantly lower mean pain scores than the ibuprofen group at 1 and 2 hours (<jats:italic>P<\/jats:italic> = 0.002), whereas at 6, 7, and 8 hours, the ibuprofen group showed statistically significantly lower mean pain scores (<jats:italic>P<\/jats:italic> &lt;0.001). Using the VRS\u20104, there was no statistically significant difference between the two groups at all periods (<jats:italic>P<\/jats:italic> &gt;0.05).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Acetaminophen, 500 mg, with caffeine, 30 mg, can be used efficiently in controlling postoperative pain after open flap debridement, especially in patients with gastric ulcers or bleeding tendency because acetaminophen is less hazardous than ibuprofen.<\/jats:p>","DOI":"10.1902\/jop.2009.080637","type":"journal-article","created":{"date-parts":[[2009,6,2]],"date-time":"2009-06-02T08:48:52Z","timestamp":1243932532000},"page":"945-952","source":"Crossref","is-referenced-by-count":21,"title":["The Efficacy of Acetaminophen\u2013Caffeine Compared to Ibuprofen in the Control of Postoperative Pain After Periodontal Surgery: A Crossover Pilot Study"],"prefix":"10.1002","volume":"80","author":[{"given":"Weam 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