{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:26:19Z","timestamp":1781789179848,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Interleukin (IL)\u201018 is a proinflammatory cytokine of the IL\u20101 superfamily and is unique, with the capacity to induce T\u2010helper (Th)1 or Th2 differentiation depending on the immunologic context. Monocyte chemoattractant protein (MCP)\u20101 is a CC chemokine responsible for chemotaxis of monocytes. A previous study showed the induction of MCP\u20101 by IL\u201018 in mice macrophages. The present study was carried out to examine the gingival crevicular fluid (GCF) levels of IL\u201018 and MCP\u20101 in periodontal health and disease and to evaluate any correlation between IL\u201018 and MCP\u20101 GCF levels.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Sixty subjects (30 males and 30 females; age range: 26 to 49 years) participated in the study. The subjects were initially divided into three groups, consisting of 20 subjects in each group, based on the gingival index, probing depth (PD), clinical attachment loss (AL), and radiologic parameters (bone loss): healthy (group 1), gingivitis (group 2), and periodontitis (group 3), whereas patients in group 3 after treatment constituted group 4. GCF samples were collected from all of the groups to estimate the levels of IL\u201018 and MCP\u20101 using enzyme\u2010linked immunosorbent assay.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The mean IL\u201018 and MCP\u20101 concentrations in GCF were highest in group 3 (330.61 pg\/\u03bcl and 73.3 pg\/\u03bcl, respectively). The results suggest that IL\u201018 and MCP\u20101 levels increased in GCF from periodontal health to disease and decreased after periodontal therapy. Levels of IL\u201018 and MCP\u20101 positively correlated with PD and clinical AL in group 3. In addition, IL\u201018 and MCP\u20101 levels significantly correlated with each other in groups 2, 3, and 4.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> GCF IL\u201018 and MCP\u20101 concentrations increased in periodontal disease compared to health and correlated positively with the severity of disease. Further, based on the positive correlation of IL\u201018 and MCP\u20101 found in this study, it can be proposed that IL\u201018 may promote an inflammatory response by the induction of MCP\u20101 production and the subsequent recruitment and activation of circulating leukocytes at the inflammatory site.<\/jats:p>","DOI":"10.1902\/jop.2009.090117","type":"journal-article","created":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T08:49:24Z","timestamp":1251794964000},"page":"1454-1461","source":"Crossref","is-referenced-by-count":46,"title":["Correlation of Gingival Crevicular Fluid Interleukin\u201018 and Monocyte Chemoattractant Protein\u20101 Levels in Periodontal Health and 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