{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:39:04Z","timestamp":1781177944322,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Enamel matrix derivative (EMD) is a composite of proteins that was demonstrated histologically to work as an adjunct to periodontal regenerative surgical therapy. The purpose of this study was to evaluate the clinical and histologic effects of EMD as an adjunct to scaling and root planing.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Four patients with severe chronic periodontitis and scheduled to receive complete dentures were accrued. Probing depth and clinical attachment levels were obtained. Unlimited time was allowed for hand and ultrasonic instrumentation. A notch was placed in the root \u22651 to 2 mm from the apical extent of root planing. EMD was inserted into the pocket, and a periodontal dressing was placed. Patients were seen every 2 weeks for plaque control. At 6 months post\u2010treatment, soft tissue measurements were repeated, and the teeth were removed en bloc and prepared for histomorphologic analysis.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Probing depth reduction and clinical attachment level gain were obtained in three\u2010fourths of the specimens. Three of the four specimens analyzed histologically demonstrated new cementum, bone, periodontal ligament, and connective tissue attachment coronal to the notch. In one specimen, the gingival margin had receded below the notch.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The results were unexpected and may represent an aberration. However, the substantial reduction in deep probing depths and clinical attachment level gain in three of four specimens, in addition to the histologic findings of new cementum, new bone, a new periodontal ligament, and a new connective tissue attachment, suggest that EMD may be useful as an adjunct to scaling and root planing in single\u2010rooted teeth.<\/jats:p>","DOI":"10.1902\/jop.2009.090160","type":"journal-article","created":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T08:49:24Z","timestamp":1251794964000},"page":"1534-1540","source":"Crossref","is-referenced-by-count":23,"title":["Clinical and Histologic Evaluation of Non\u2010Surgical Periodontal Therapy With Enamel Matrix Derivative: A Report of Four Cases"],"prefix":"10.1002","volume":"80","author":[{"given":"James T.","family":"Mellonig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Valderrama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly J.","family":"Gregory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Cochran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00251.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000100386"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130401500605"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00247.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00249.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.7.1001"},{"key":"e_1_2_7_8_1","first-page":"127","article-title":"A case report of 72 consecutive Emdogain\u2010treated intrabony periodontal defects: Clinical and radiographic findings after 1 year","volume":"20","author":"Heden G","year":"2000","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.12.1821"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.1.25"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.5.752"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708600106"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708601012"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200102000-00013"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7270.2007.00250.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.10016"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2008.02.033"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060111"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070311"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21142"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2002.290110.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.07.025"},{"key":"e_1_2_7_23_1","first-page":"30","article-title":"The limits of subgingival scaling","volume":"1","author":"Stambaugh RV","year":"1981","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1989.60.1.67"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb01309.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2002.290102.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00374.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00664.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1937.0055"},{"key":"e_1_2_7_30_1","first-page":"35","volume-title":"Regeneration of the Periodontal Attachment in Humans","author":"Dragoo M","year":"1981"},{"key":"e_1_2_7_31_1","first-page":"8","article-title":"Experimental periodontal treatment in humans. 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