{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:32:26Z","timestamp":1792452746573,"version":"4.5.0"},"reference-count":60,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    This study compared the subgingival microbiota of subjects with refractory periodontitis (RP) to those in subjects with treatable periodontitis (GRs = good responders) or periodontal health (PH) using the Human Oral Microbe Identification Microarray (HOMIM).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    At baseline, subgingival plaque samples were taken from 47 subjects with periodontitis and 20 individuals with PH and analyzed for the presence of 300 species by HOMIM. The subjects with periodontitis were classified as having RP (n = 17) based on mean attachment loss (AL) and\/or more than three sites with AL \u22652.5 mm after scaling and root planing, surgery, and systemically administered amoxicillin and metronidazole or as GRs (n = 30) based on mean attachment gain and no sites with AL \u22652.5 mm after treatment. Significant differences in taxa among the groups were sought using the Kruskal\u2010Wallis and \u03c7\n                    <jats:sup>2<\/jats:sup>\n                    tests.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    More species were detected in patients with disease (GR or RP) than in those without disease (PH). Subjects with RP were distinguished from GRs or those with PH by a significantly higher frequency of putative periodontal pathogens, such as\n                    <jats:italic>Parvimonas micra<\/jats:italic>\n                    (previously\n                    <jats:italic>Peptostreptococcus micros<\/jats:italic>\n                    or\n                    <jats:italic>Micromonas micros<\/jats:italic>\n                    ),\n                    <jats:italic>Campylobacter gracilis, Eubacterium nodatum, Selenomonas noxia, Tannerella forsythia<\/jats:italic>\n                    (previously\n                    <jats:italic>T. forsythensis<\/jats:italic>\n                    ),\n                    <jats:italic>Porphyromonas gingivalis, Prevotella<\/jats:italic>\n                    spp.,\n                    <jats:italic>Treponema<\/jats:italic>\n                    spp., and\n                    <jats:italic>Eikenella corrodens<\/jats:italic>\n                    , as well as unusual species (\n                    <jats:italic>Pseudoramibacter alactolyticus<\/jats:italic>\n                    , TM7 spp. oral taxon [OT] 346\/356,\n                    <jats:italic>Bacteroidetes<\/jats:italic>\n                    sp. OT 272\/274,\n                    <jats:italic>Solobacterium moorei, Desulfobulbus<\/jats:italic>\n                    sp. OT 041,\n                    <jats:italic>Brevundimonas diminuta, Sphaerocytophaga<\/jats:italic>\n                    sp. OT 337,\n                    <jats:italic>Shuttleworthia satelles, Filifactor alocis, Dialister invisus\/pneumosintes, Granulicatella adiacens, Mogibacterium timidum, Veillonella atypica, Mycoplasma salivarium, Synergistes<\/jats:italic>\n                    sp. cluster II, and\n                    <jats:italic>Acidaminococcaceae<\/jats:italic>\n                    [G\u20101] sp. OT 132\/150\/155\/148\/135) (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). Species that were more prevalent in subjects with PH than in patients with periodontitis included\n                    <jats:italic>Actinomyces<\/jats:italic>\n                    sp. OT 170,\n                    <jats:italic>Actinomyces<\/jats:italic>\n                    spp. cluster I,\n                    <jats:italic>Capnocytophaga sputigena, Cardiobacterium hominis, Haemophilus parainfluenzae, Lautropia mirabilis, Propionibacterium propionicum, Rothia dentocariosa\/mucilaginosa<\/jats:italic>\n                    , and\n                    <jats:italic>Streptococcus sanguinis<\/jats:italic>\n                    (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    As determined by HOMIM, patients with RP presented a distinct microbial profile compared to patients in the GR and PH groups.\n                  <\/jats:p>","DOI":"10.1902\/jop.2009.090185","type":"journal-article","created":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T08:49:24Z","timestamp":1251794964000},"page":"1421-1432","source":"Crossref","is-referenced-by-count":496,"title":["Comparisons of Subgingival Microbial Profiles of Refractory Periodontitis, Severe Periodontitis, and Periodontal Health Using the Human Oral Microbe Identification Microarray"],"prefix":"10.1002","volume":"80","author":[{"given":"Ana Paula V.","family":"Colombo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan K.","family":"Boches","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean L.","family":"Cotton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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