{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:49:51Z","timestamp":1785836991253,"version":"3.56.0"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Platelet\u2010rich plasma (PRP) alone or combined with other regenerative materials was previously studied in human periodontal endosseous defects. There are no sufficient data evaluating to what extent the addition of demineralized freeze\u2010dried bone allograft (DFDBA) to PRP may enhance the effectiveness of PRP. The aim of this randomized, double\u2010masked, controlled clinical trial was to compare the effectiveness of autologous PRP alone to PRP + DFDBA in periodontal endosseous defects.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty\u2010four proximal endosseous defects in 24 patients with severe chronic periodontitis were randomly treated with PRP alone or in combination with DFDBA. The final evaluation at 6 months was based on clinical and radiographic parameters. Subtraction radiography was used. The primary outcome variable was clinical attachment level (CAL).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The two treatment groups were initially comparable (mean CAL: 8.67 \u00b1 2.19 mm for PRP + DFDBA and 8.25 \u00b1 1.96 mm for PRP). Both treatments achieved statistically significant and similar CAL gain (3.08 \u00b1 1.17 mm for PRP + DFDBA and 3.08 \u00b1 0.95 mm for PRP), probing depth, defect depth, and area surface reduction. The percentage of defect fill did not significantly differ between the two treatments. There was a non\u2010significant trend to greater defect fill (45.42% versus 41.29%), defect depth (54.05% versus 49.52%), and area surface (58.43% versus 52.16%) reduction with the graft. In both groups, 66.66% of the defects gained \u22653 mm of CAL.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Within its limits, this study demonstrates that both PRP and PRP combined with DFDBA resulted in significant clinical and radiographic improvement in human periodontal endosseous defects at 6 months, and the addition of DFDBA to PRP did not significantly enhance the treatment outcome.<\/jats:p>","DOI":"10.1902\/jop.2009.090216","type":"journal-article","created":{"date-parts":[[2009,12,7]],"date-time":"2009-12-07T08:57:14Z","timestamp":1260176234000},"page":"1911-1919","source":"Crossref","is-referenced-by-count":48,"title":["Treatment of Periodontal Endosseous Defects With Platelet\u2010Rich Plasma Alone or in Combination With Demineralized Freeze\u2010Dried Bone Allograft: A Comparative Clinical Trial"],"prefix":"10.1002","volume":"80","author":[{"given":"Nikolaos","family":"Markou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eudoxie","family":"Pepelassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Vavouraki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry C.","family":"Stamatakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Nikolopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Vrotsos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostas","family":"Tsiklakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.4.929.bloodjournal854929"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.902904.x"},{"key":"e_1_2_7_4_1","first-page":"2","article-title":"Growth factor stimulation of bone healing. 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