{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:51:00Z","timestamp":1789977060706,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Interleukin (IL)\u20101\u03b2 gene polymorphisms are considered a potential risk factor for periodontal disease. The aim of this study is to identify the association of IL\u20101\u03b2 gene polymorphisms with chronic periodontitis and aggressive periodontitis in a Malayalam\u2010speaking Dravidian population from South India.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The case\u2010control study consisted of 43 patients with chronic periodontitis and 54 patients with aggressive periodontitis as cases, and the control group consisted of 101 healthy subjects. All subjects were genotyped for IL\u20101\u03b2 +3954, \u2212511, and \u221231 loci by polymerase chain reaction amplification followed by restriction enzyme digestion and gel electrophoresis. Genotype, allele, and haplotype analyses were done.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Analyses for allele and genotypes showed a high frequency of the C allele and CC genotype for single nucleotide polymorphism IL\u20101\u03b2 +3954 in the group with chronic periodontitis and no difference for patients with aggressive periodontitis compared to controls (<jats:italic>P<\/jats:italic> &lt;0.05). Haplotype analysis showed that IL\u20101\u03b2 \u221231 and \u2212511 were in strong linkage disequilibrium in all groups. The IL\u20101\u03b2 \u221231 allele T was in linkage with allele T of IL\u20101\u03b2 +3954 in the control group.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> In the Malayalam\u2010speaking Dravidian population, allele C of IL\u20101\u03b2 +3954 appeared to be an important risk factor for chronic periodontitis. The IL\u20101\u03b2 \u221231 allele T was in linkage with allele T of IL\u20101\u03b2 +3954 in the control group. No gene polymorphisms were found in patients with aggressive periodontitis. More studies with a larger sample size involving the entire cluster of the IL\u20101\u03b2 gene are necessary to determine the exact role of IL\u20101\u03b2 gene polymorphisms in periodontal disease.<\/jats:p>","DOI":"10.1902\/jop.2009.090256","type":"journal-article","created":{"date-parts":[[2010,1,11]],"date-time":"2010-01-11T03:56:32Z","timestamp":1263182192000},"page":"62-69","source":"Crossref","is-referenced-by-count":33,"title":["Association of Single Nucleotide Gene Polymorphism at Interleukin\u20101\u03b2 +3954, \u2212511, and \u221231 in Chronic Periodontitis and Aggressive Periodontitis in Dravidian Ethnicity"],"prefix":"10.1002","volume":"81","author":[{"given":"Abhijeet Rajendra","family":"Shete","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosamma","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neetha N.","family":"Vijayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lekshmy","family":"Srinivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moinak","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.10s.1041"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00199.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1994.tb00020.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.821"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00194.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6713.2004.003561.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb01187.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.2.164"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.12.1796"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.291002.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.4.418"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20310"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060264"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1967.38.6_part2.610"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1964.0034"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_7_19_1","first-page":"48","volume-title":"Molecular Cloning. 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