{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:33:03Z","timestamp":1760920383453,"version":"build-2065373602"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> We previously reported a high prevalence of a combination of alleles 2 at positions <jats:italic>interleukin<\/jats:italic> (<jats:italic>IL)\u20101A<jats:sup>\u2212889<\/jats:sup><\/jats:italic> and <jats:italic>IL\u20101B<jats:sup>+3954<\/jats:sup><\/jats:italic> in an Arabic population with gingivitis. In a steady state, the proportion of sites with bleeding on probing (BOP) was consistently reduced. The aim of the present study is to expand this observation by considering the site level.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Fifty healthy non\u2010smoking volunteers, 19 to 28 years of age, participated in this study. Clinical examinations included probing depth, BOP, plaque index (PI), and calculus. Examinations were repeated after 2 and 4 weeks, and subjects were advised not to change oral hygiene habits. Polymorphisms in the IL\u20101 gene cluster were assessed using a reverse hybridization assay.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Twenty\u2010six subjects (52%) carried alleles 2 at positions <jats:italic>IL\u20101A<jats:sup>\u2212889<\/jats:sup><\/jats:italic> and <jats:italic>IL\u20101B<jats:sup>+3954<\/jats:sup><\/jats:italic> and were designated genotype positive. In multivariate multilevel models of BOP, bleeding tendency in subjects with positive IL\u20101 genotype was only reduced at sites with PI 0 (odds ratio of 0.98, 0.65, and 0.56 at baseline and 2 and 4 weeks, respectively; \u03c7<jats:sup>2<\/jats:sup><jats:sub>(3)<\/jats:sub> = 11.946; <jats:italic>P<\/jats:italic> = 0.008) or 1 (\u03c7<jats:sup>2<\/jats:sup><jats:sub>(3)<\/jats:sub> = 6.027; <jats:italic>P<\/jats:italic> = 0.110). A decreased bleeding tendency at certain tooth types in subjects who were IL\u20101 positive was largely related to the relative cleanliness of these areas. Random parts of the models revealed very low biserial correlations of 0.13 to 0.15 at the site level, whereas correlations were considerably higher (0.76 to 0.83) at the subject level.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Multilevel modeling of site\u2010specific data yielded new information about the influence of the IL\u20101 genotype in plaque\u2010induced gingivitis.<\/jats:p>","DOI":"10.1902\/jop.2009.090315","type":"journal-article","created":{"date-parts":[[2010,1,11]],"date-time":"2010-01-11T03:56:32Z","timestamp":1263182192000},"page":"52-61","source":"Crossref","is-referenced-by-count":6,"title":["Site\u2010Specific Gingival Bleeding on Probing in a Steady\u2010State Plaque Environment: Influence of Polymorphisms in the Interleukin\u20101 Gene Cluster"],"prefix":"10.1002","volume":"81","author":[{"given":"Hans\u2010Peter","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kefah M.","family":"Barrieshi\u2010Nusair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,1]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1007\/s007840100126"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1111\/j.1600-051X.1992.tb00673.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.1111\/j.1600-051X.1995.tb00818.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1111\/j.1600-051x.2004.00478.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.1007\/s007840000078"},{"doi-asserted-by":"publisher","key":"e_1_2_7_7_1","DOI":"10.1111\/j.1600-051x.2004.00477.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_1","DOI":"10.1111\/j.1600-051X.2005.00810.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_9_1","DOI":"10.1111\/j.1600-051X.1997.tb01187.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_10_1","DOI":"10.1902\/jop.2000.71.2.156"},{"doi-asserted-by":"publisher","key":"e_1_2_7_11_1","DOI":"10.1902\/jop.1999.70.1.49"},{"doi-asserted-by":"publisher","key":"e_1_2_7_12_1","DOI":"10.1902\/jop.2005.76.2.234"},{"doi-asserted-by":"publisher","key":"e_1_2_7_13_1","DOI":"10.1016\/j.ygeno.2008.07.004"},{"doi-asserted-by":"publisher","key":"e_1_2_7_14_1","DOI":"10.1034\/j.1600-051X.2003.00218.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_15_1","DOI":"10.1902\/jop.2005.76.1.49"},{"doi-asserted-by":"publisher","key":"e_1_2_7_16_1","DOI":"10.1034\/j.1600-0765.2000.035002102.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_17_1","DOI":"10.1007\/s00784-007-0120-5"},{"doi-asserted-by":"publisher","key":"e_1_2_7_18_1","DOI":"10.1111\/j.1600-0765.1999.tb02265.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_19_1","DOI":"10.1002\/sim.1264"},{"doi-asserted-by":"publisher","key":"e_1_2_7_20_1","DOI":"10.1007\/s00784-008-0237-1"},{"unstructured":"World Medical Association Declaration of Helsinki.http:\/\/www.wma.net\/en\/30publications\/10policies\/b3\/index.html. 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