{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:44:52Z","timestamp":1791927892654,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> 25\u2010hydroxy vitamin D<jats:sub>3<\/jats:sub> is the major circulating metabolite of vitamin D. Elevated plasma 25\u2010hydroxy vitamin D<jats:sub>3<\/jats:sub> levels were verified to be associated with generalized aggressive periodontitis (GAgP). In the present study, the influence of initial periodontal therapy on systemic and local levels of 25\u2010hydroxy vitamin D<jats:sub>3<\/jats:sub> and three related elements (osteocalcin and interleukin\u20101\u03b2 and \u20106) in patients with GAgP was investigated.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Nineteen patients with GAgP were enrolled. All patients received initial periodontal therapy. Gingival crevicular fluid at two sites of each subject were obtained before therapy and 2 and 6 months after therapy. Plasma was obtained before and 2 months after therapy from 12 of 19 subjects. Systemic and local levels of 25\u2010hydroxy vitamin D<jats:sub>3<\/jats:sub>, osteocalcin, and interleukin\u20101\u03b2 and \u20106 before and after therapy were measured using radioimmunoassay or enzyme\u2010linked immunosorbent assay kits and compared.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The respective systemic 25\u2010hydroxy vitamin D<jats:sub>3<\/jats:sub> and interleukin\u20101\u03b2 levels significantly dropped from baseline to 2 months after therapy (29.28 nmol\/l versus 22.50 nmol\/l, <jats:italic>P<\/jats:italic> = 0.001, and 6.71 ng\/l versus 3.23 ng\/l, <jats:italic>P<\/jats:italic> &lt;0.001, respectively). The respective local 25\u2010hydroxy vitamin D<jats:sub>3<\/jats:sub> and interleukin\u20101\u03b2 levels significantly decreased from baseline to 2 and 6 months after therapy (8,950 nmol\/l versus 5,650 nmol\/l versus 3,438 nmol\/l, <jats:italic>P<\/jats:italic> &lt;0.001, and 10,595 ng\/l versus 5,495 ng\/l versus 3,960 ng\/l, <jats:italic>P<\/jats:italic> &lt;0.001, respectively). Systemic and local 25\u2010hydroxy vitamin D<jats:sub>3<\/jats:sub> concentrations were positively correlated at baseline (r = 0.877; <jats:italic>P<\/jats:italic> = 0.022), as was osteocalcin (r = 0.939; <jats:italic>P<\/jats:italic> = 0.005).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> 25\u2010hydroxy vitamin D<jats:sub>3<\/jats:sub> and interleukin\u20101\u03b2 levels were systemically and locally reduced in patients with GAgP by initial periodontal therapy. 25\u2010hydroxy vitamin D<jats:sub>3<\/jats:sub> might be involved in periodontal inflammation.<\/jats:p>","DOI":"10.1902\/jop.2009.090355","type":"journal-article","created":{"date-parts":[[2010,2,12]],"date-time":"2010-02-12T12:46:09Z","timestamp":1265978769000},"page":"260-266","source":"Crossref","is-referenced-by-count":44,"title":["Initial Periodontal Therapy Reduced Systemic and Local 25\u2010Hydroxy Vitamin D<sub>3<\/sub> and Interleukin\u20101\u03b2 in Patients With Aggressive Periodontitis"],"prefix":"10.1002","volume":"81","author":[{"given":"Kaining","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanxin","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghui","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080675"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1981.tb02031.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10423"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2003.03108.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.02002.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1996.0097q.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.29.2246"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/1042819032000159924"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2006.10.007"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.136.7.2478"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.8.2632"},{"key":"e_1_2_7_13_1","first-page":"24","article-title":"Levels of interleukin\u20101beta and tumor necrosis factor\u2010alpha in patients with aggressive periodontitis (in Chinese)","volume":"40","author":"Sun XJ","year":"2008","journal-title":"Beijing Da Xue Xue Bao"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01213.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0953-6205(02)00132-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2005-0490"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2008.01131.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060286"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.1.68"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02478.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1937.10503522"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.041105"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0174-173X(85)80017-0"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/00003086-198801000-00036","article-title":"Osteocalcin. 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