{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:48:55Z","timestamp":1789847335067,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of the study is to clinically and histologically evaluate the healing of advanced intrabony defects treated with open flap debridement and the adjunct implantation of granular beta tricalcium phosphate (\u03b2\u2010TCP).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Five patients, each displaying advanced combined 1\u2010 and 2\u2010wall intrabony defects around teeth scheduled for extraction or root resection, were recruited. Approximately 6 months after surgery, the teeth or roots were removed together with a portion of their surrounding soft and hard tissues and processed for histologic evaluation.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The mean probing depth (PD) was reduced from 10.8 \u00b1 2.3 mm presurgically to 4.6 \u00b1 2.1 mm, whereas a mean clinical attachment level (CAL) gain of 5.0 \u00b1 0.7 mm was observed. The increase in gingival recession was 1.2 \u00b1 3.2 mm. The histologic evaluation indicated the formation of new cellular cementum with inserting collagen fibers to a varying extent (mean: 1.9 \u00b1 0.7 mm; range: 1.2 to 3.03 mm) coronal to the most apical extent of the root instrumentation. The mean new bone formation was 1.0 \u00b1 0.7 mm (range: 0.0 to 1.9 mm). In most specimens, \u03b2\u2010TCP particles were embedded in the connective tissue, whereas the formation of a mineralized bone\u2010like or cementum\u2010like tissue around the particles was only occasionally observed.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The present data indicates that treatment of intrabony periodontal defects with this \u03b2\u2010TCP may result in substantial clinical improvements such as PD reduction and CAL gain, but this \u03b2\u2010TCP does not seem to enhance the regeneration of cementum, periodontal ligament, and bone.<\/jats:p>","DOI":"10.1902\/jop.2009.090386","type":"journal-article","created":{"date-parts":[[2010,2,12]],"date-time":"2010-02-12T12:46:09Z","timestamp":1265978769000},"page":"325-334","source":"Crossref","is-referenced-by-count":59,"title":["Clinical and Histologic Evaluation of Granular Beta\u2010Tricalcium Phosphate for the Treatment of Human Intrabony Periodontal Defects: A Report on Five Cases"],"prefix":"10.1002","volume":"81","author":[{"given":"Andreas","family":"Stavropoulos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Windisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora","family":"Szendr\u00f6i\u2010Kiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosta","family":"Peter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n","family":"Gera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00951.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1993.tb00209.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1999.tb00148.x"},{"key":"e_1_2_7_5_1","volume-title":"Guided tissue regeneration in combination with deproteinized bovine bone and gentamicin","author":"Stavropoulos A","year":"2002"},{"key":"e_1_2_7_6_1","first-page":"650","volume-title":"Clinical Periodontology and Implant Dentistry","author":"Karring T","year":"2003"},{"key":"e_1_2_7_7_1","volume-title":"Periodontal Regeneration","author":"Wikesj\u00f6 UM","year":"2010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1973.44.10.614"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1973.44.10.599"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1978.49.10.495"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1983.54.2.67"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1989.60.12.683"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1989.60.12.675"},{"key":"e_1_2_7_14_1","first-page":"321","article-title":"Clinical, radiographic, and histologic evaluation of human periodontal defects treated with Bio\u2010Oss and Bio\u2010Gide","volume":"18","author":"Camelo M","year":"1998","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.3463"},{"key":"e_1_2_7_16_1","first-page":"146","article-title":"Periodontal regeneration following use of ABM\/P\u20101 5: A case report","volume":"22","author":"Yukna R","year":"2002","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-5182(05)80093-9"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198406000-00014"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-1298(20)31926-X"},{"issue":"251","key":"e_1_2_7_20_1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00003086-199002000-00042","article-title":"Human immunodeficiency virus cultured from bone. 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