{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:32:41Z","timestamp":1768005161329,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Minimally invasive surgery (MIS) is a surgical technique using very small incisions indicated for performing regenerative therapy in periodontal defects. The 11\u2010month results from a prospective study of MIS were previously published. This article presents the 6\u2010year results of that prospective study.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Patients from two private periodontal practices with advanced periodontitis who, after non\u2010surgical therapy, had one or more sites with probing depths \u22656 mm were included in the study. An MIS surgical approach was used for all sites \u22656 mm. After surgical debridement, enamel matrix derivative (EMD) was placed into the bony defect. The surgical sites were reevaluated after \u22656 years.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Six\u2010year data were available on 142 sites in 13 patients. No significant differences were noted in the results between the two offices, and the data were combined. Probing depths (mean: 3.18 mm; SD: 0.59 mm) and attachment levels (mean: 3.93 mm; SD: 0.19) at 6 years were unchanged from the 11\u2010month measurements. No recession from preoperative levels was noted. All sites continued to be considered clinically successful.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The combination of MIS and EMD yielded significant reductions in probing depths and improvements in attachment levels while producing no detectable recession. The 11\u2010month results remained stable at 6 years.<\/jats:p>","DOI":"10.1902\/jop.2009.090393","type":"journal-article","created":{"date-parts":[[2010,3,2]],"date-time":"2010-03-02T04:12:41Z","timestamp":1267503161000},"page":"435-441","source":"Crossref","is-referenced-by-count":42,"title":["Prospective Assessment of the Use of Enamel Matrix Derivative With Minimally Invasive Surgery: 6\u2010Year Results"],"prefix":"10.1002","volume":"81","author":[{"given":"Stephen K.","family":"Harrel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Thomas G.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha E.","family":"Nunn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800770702"},{"key":"e_1_2_7_3_1","first-page":"3","volume-title":"Minimally Invasive Surgery","author":"Hunter JG","year":"1993"},{"key":"e_1_2_7_4_1","first-page":"960, 962, 964","article-title":"Granulation tissue removal in routine and minimally invasive procedures","volume":"16","author":"Harrel SK","year":"1995","journal-title":"Compend Contin Educ Dent"},{"key":"e_1_2_7_5_1","first-page":"161","article-title":"A minimally invasive surgical approach for periodontal bone grafting","volume":"18","author":"Harrel SK","year":"1998","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.12.1547"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.11.1761"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.11.1509"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.3.380"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.01020.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01144.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01242.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.00610.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.7.1043"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.8.1278"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.8.942"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.1.3"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080259"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080009"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.10.1309"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.4.485"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.621"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2009.090393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:21:03Z","timestamp":1760883663000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2009.090393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1902\/jop.2009.090393"],"URL":"https:\/\/doi.org\/10.1902\/jop.2009.090393","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}