{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:49:50Z","timestamp":1790192990637,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Diabetes and periodontitis produce a protein discharge that can be reflected in saliva. This study evaluates the salivary concentrations of interleukin (IL)\u20106, matrix metalloproteinase (MMP)\u20108, and osteoprotegerin (OPG) in patients with periodontitis with type 2 diabetes.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Whole saliva samples were obtained from 90 subjects who were divided into four groups: healthy (control; n = 22), untreated periodontitis (UPD; n = 24), diabetes mellitus (DM; n = 20), and UPD + DM (n = 24) groups. Clinical and metabolic data were recorded. Salivary IL\u20106, MMP\u20108, and OPG concentrations were determined by a standard enzyme\u2010linked immunosorbent assay.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The UPD and UPD + DM groups exhibited higher salivary IL\u20106 than the control and DM groups (<jats:italic>P<\/jats:italic> &lt;0.01). The salivary MMP\u20108 concentrations in all diseased groups (UPD, DM, and UPD + DM) were higher than in the control group (<jats:italic>P<\/jats:italic> &lt;0.01). The salivary OPG concentrations in the DM group were higher than in the UPD and control groups (<jats:italic>P<\/jats:italic> &lt;0.05). In the UPD + DM group, salivary IL\u20106 was correlated with glycated hemoglobin (HbA1c) levels (r = 0.60; <jats:italic>P<\/jats:italic> &lt;0.05). The regression analysis indicated that the number of remaining teeth, clinical attachment level, and IL\u20106 might have influenced the HbA1c levels in patients with diabetes.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Salivary IL\u20106 concentrations were elevated in patients with periodontitis with or without diabetes. Salivary MMP\u20108 and OPG concentrations were elevated regardless of periodontal inflammation in patients with diabetes. Therefore, periodontitis and diabetes are conditions that may interfere with protein expression and should be considered when using saliva for diagnoses.<\/jats:p>","DOI":"10.1902\/jop.2009.090510","type":"journal-article","created":{"date-parts":[[2010,3,2]],"date-time":"2010-03-02T04:12:41Z","timestamp":1267503161000},"page":"384-391","source":"Crossref","is-referenced-by-count":142,"title":["Salivary Interleukin\u20106, Matrix Metalloproteinase\u20108, and Osteoprotegerin in Patients With Periodontitis and Diabetes"],"prefix":"10.1002","volume":"81","author":[{"given":"Priscila P.","family":"Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glauce L.","family":"Trevisan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme O.","family":"Macedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela B.","family":"Palioto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio L.S.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio F.M.","family":"Grisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Arthur B.","family":"Novaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Mario","family":"Taba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2004.04.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2006.00883.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-S062"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2007.00219.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2006.01348.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.290103.x"},{"key":"e_1_2_7_8_1","unstructured":"National Institute of Diabetes and Digestive and Kidney Diseases \u2013 NIDDK.National Diabetes Statistics 2007. Available at:www.diabetes.niddk.nih.gov\/pubs\/statistics. Accessed on July 8 2009."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0906-6713.2002.003422.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080070"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2005.03.009"},{"key":"e_1_2_7_12_1","first-page":"S11","article-title":"Interleukin\u20106: A key mediator of systemic and local symptoms in rheumatoid arthritis","volume":"65","author":"Cronstein BN","year":"2007","journal-title":"Bull NYU Hosp Jt Dis"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.050451"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1384.035"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1384.034"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81569-X"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2006.0181"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2006.00187.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027007453.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070168"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070348"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00822.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb18343.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1917"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8942"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.9.1361"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(94)90137-6"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00193.x"},{"key":"e_1_2_7_30_1","first-page":"841","article-title":"Periodontal disease as a potential risk factor for systemic diseases","volume":"69","author":"Scannapieco FA","year":"1998","journal-title":"J Periodontol"},{"key":"e_1_2_7_31_1","first-page":"65","article-title":"Periodontal disease progression in type II non\u2010insulin\u2010dependent diabetes mellitus patients (NIDDM). Part I \u2013 Probing pocket depth and clinical attachment","volume":"7","author":"Novaes AB","year":"1996","journal-title":"Braz Dent J"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.01032.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2001.6.1.125"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.568"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb01814.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2000.035005259.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050293"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb00454.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00545.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.2.631"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0906-6713.2002.03206.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05494-0"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000031524.49139.29"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0231"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2009.090510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:21:05Z","timestamp":1760883665000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2009.090510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1902\/jop.2009.090510"],"URL":"https:\/\/doi.org\/10.1902\/jop.2009.090510","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}