{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:38:56Z","timestamp":1760920736635,"version":"build-2065373602"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Antimicrobial peptides participating in the innate host response are important contributors for maintaining the balance between health and disease. The aim of the present study is to investigate the levels of gingival crevicular fluid (GCF) adrenomedullin and human neutrophil peptides 1 through 3 (HNP1\u20133) in patients with different periodontal diseases.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A total of 77 subjects, including 20 patients with chronic periodontitis, 18 patients with generalized aggressive periodontitis, 20 patients with gingivitis, and 19 healthy subjects, were included in the present study. The probing depth, clinical attachment level, plaque index, and papilla bleeding index were assessed in all study subjects. GCF samples were analyzed for evaluating adrenomedullin and HNP1\u20133 levels by enzyme\u2010linked immunosorbent assay.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The present study demonstrated that the periodontitis groups had a significantly higher total amount of GCF adrenomedullin compared to the gingivitis and healthy control groups after adjusting for age and gender (<jats:italic>P<\/jats:italic> &lt;0.05). Additionally, GCF adrenomedullin levels were positively correlated with clinical periodontal parameters of sampling sites (<jats:italic>P<\/jats:italic> &lt;0.05). The total amount of GCF HNP1\u20133 was not different among the study groups, and there was no correlation between the total amount of GCF HNP1\u20133 and clinical periodontal parameters (<jats:italic>P<\/jats:italic> &gt;0.05).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Our results suggest a defensive role for adrenomedullin during the host response in periodontal disease. Additionally, the lack of the HNP1\u20133 antimicrobial peptide might point to the deficiency of one of the protective mechanisms for periodontal tissues.<\/jats:p>","DOI":"10.1902\/jop.2009.090517","type":"journal-article","created":{"date-parts":[[2010,2,12]],"date-time":"2010-02-12T12:46:09Z","timestamp":1265978769000},"page":"284-291","source":"Crossref","is-referenced-by-count":24,"title":["Evaluation of Gingival Crevicular Fluid Adrenomedullin and Human Neutrophil Peptide 1\u20133 Levels of Patients With Different Periodontal 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