{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T04:29:23Z","timestamp":1773548963890,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Human papillomavirus (HPV)\u201016 is detected in normal oral mucosa and several oral lesions, including squamous cell carcinoma, condyloma acuminatum, verruca vulgaris, focal epithelial hyperplasia, and periodontal diseases. It was hypothesized that HPV may be involved in periodontal breakdown and that periodontal tissue acts as a reservoir for the virus. Therefore, in this study, the prevalence of HPV\u201016 in the gingival tissue of Brazilians with periodontal health or disease is investigated.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold>: Fifty\u2010six gingival samples from subjects with chronic periodontitis, 26 samples from subjects with gingivitis, and 22 samples from subjects with healthy peridontium were analyzed. Total DNA was extracted, and the presence of HPV\u201016 was assessed using a real\u2010time polymerase chain reaction. Positive and negative controls were included in the reactions.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> HPV\u201016 was not detected in any of the 104 gingival samples evaluated; therefore, this virus showed no association with periodontal disease in this study.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> In the population studied, HPV\u201016 may not have participated in the pathogenesis of chronic periodontitis, and the gingival tissue did not act as a reservoir for this virus.<\/jats:p>","DOI":"10.1902\/jop.2009.090571","type":"journal-article","created":{"date-parts":[[2010,4,5]],"date-time":"2010-04-05T05:19:23Z","timestamp":1270444763000},"page":"562-568","source":"Crossref","is-referenced-by-count":22,"title":["Human Papillomavirus\u201016 Prevalence in Gingival Tissue and Its Association With Periodontal Destruction: A Case\u2010Control Study"],"prefix":"10.1002","volume":"81","author":[{"given":"Ver\u00f4nica 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