{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:30:41Z","timestamp":1760920241043,"version":"build-2065373602"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE07309\u201006"],"award-info":[{"award-number":["DE07309\u201006"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The goal of this study is to determine whether HIV infection or high\u2010risk behaviors associated with HIV infection are related to alveolar bone loss in a sample of subjects screened at a dental school clinic.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Subjects were included in this study (N = 355) if they were HIV positive or had high\u2010risk behaviors associated with HIV infection as identified by health risk behavior screening questionnaire. Bone loss measurements were obtained from radiographs. Both bivariate relationships and multivariate relationships between alveolar bone loss and three sets of variables were evaluated: high\u2010risk behavior questions, demographic variables, and HIV infection.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The following variables were found related to alveolar bone loss in bivariate relationships: age (<jats:italic>P<\/jats:italic> \u22640.0001); smoking (pack\u2010years) (<jats:italic>P<\/jats:italic> \u22640.0001); race (<jats:italic>P<\/jats:italic> \u22640.002); gender (<jats:italic>P<\/jats:italic> \u22640.032); male\u2010male sex (<jats:italic>P<\/jats:italic> &lt;0.001); diabetes (<jats:italic>P<\/jats:italic> \u22640.015); sharing of needles (<jats:italic>P<\/jats:italic> \u22640.02); and hepatitis C positive (<jats:italic>P<\/jats:italic> \u22640.05). In the multiple regression model, age, smoking, race, gender, and male\u2010male sex remained significant. In both analyses, HIV\u2010positive individuals had similar bone loss compared to those who were HIV negative.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> These results suggest that HIV infection is not related to alveolar bone loss in individuals with high\u2010risk behaviors for HIV infection. These results also suggest that previously reported relationships between HIV infection and increased alveolar bone loss may be explained by other factors, such as smoking. Individuals in this study population with risk behaviors associated with HIV infection smoked at a high rate and, because of the smoking behavior, have a high rate of periodontal disease.<\/jats:p>","DOI":"10.1902\/jop.2010.070675","type":"journal-article","created":{"date-parts":[[2010,4,9]],"date-time":"2010-04-09T11:43:23Z","timestamp":1270813403000},"page":"877-884","source":"Crossref","is-referenced-by-count":9,"title":["HIV Infection and Bone Loss Due to Periodontal Disease"],"prefix":"10.1002","volume":"81","author":[{"given":"Mary E.","family":"Aichelmann\u2010Reidy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dena L.","family":"Wrigley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John 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