{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:54:02Z","timestamp":1787792042491,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The purpose of this study is to clinically and microbiologically evaluate the effect of photodynamic therapy (PDT) as a full\u2010mouth procedure in <jats:italic>Fusobacterium nucleatum<\/jats:italic>\u2013infected patients with periodontitis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> In the present study, PDT is administered adjuvantly after scaling and root planing (SRP) to patients with localized chronic periodontitis (LCP). Twenty\u2010four patients, in whom only <jats:italic>F. nucleatum<\/jats:italic> was detected by baseline polymerase chain reaction (PCR) after SRP, were randomly assigned to PDT and control groups. PDT was carried out once as a full\u2010mouth disinfection in the test group. The control group was treated with the photosensitizer solution, but without laser irradiation. In all subjects, the clinical parameters plaque index, reddening, bleeding on probing (BOP), probing depth (PD), gingival recession, and clinical attachment level (CAL) were determined at the baseline examination and at 1, 4, and 12 weeks after PDT. Quantitative analysis of the <jats:italic>F. nucleatum<\/jats:italic> DNA concentration was performed by competitive PCR. All clinical indices were calculated for each test and control subject as were the median and interquartile range of each group.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> In patients with LCP who received PDT treatment, significant reductions in reddening, BOP, and mean PD and CAL were observed during the observation period and with respect to controls. Four and 12 weeks after PDT, the mean PD and CAL showed significant differences from baseline values and from those of the control group. In the PDT group, 12 weeks after treatment, the <jats:italic>F. nucleatum<\/jats:italic> DNA concentration was found to be significantly reduced compared to the baseline level.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The results of this study show that the adjuvant application of the described PDT method is appropriate to reduce periodontal inflammatory symptoms and to successfully treat infection with <jats:italic>F. nucleatum<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.2010.090246","type":"journal-article","created":{"date-parts":[[2010,3,29]],"date-time":"2010-03-29T12:39:13Z","timestamp":1269866353000},"page":"975-981","source":"Crossref","is-referenced-by-count":82,"title":["Full\u2010Mouth Antimicrobial Photodynamic Therapy in <i>Fusobacterium nucleatum<\/i>\u2013Infected Periodontitis Patients"],"prefix":"10.1002","volume":"81","author":[{"given":"Bernd W.","family":"Sigusch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Engelbrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"V\u00f6lpel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Holletschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Sch\u00fctze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.54.1.413"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00199.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/19424396.2001.12223184"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-8532(03)00039-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.9.s1.6.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00493.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/42.1.13"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(92)90058-G"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1998.tb09694.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/b311904c"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.10.1343"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.3.932-940.2003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2001.012002104.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.7.1100"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060494"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090285"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01232.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.6.991"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.3.275"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0909-8836.1999.eos107201.x"},{"key":"e_1_2_7_23_1","first-page":"229","article-title":"Efficacy of photodynamic therapy on clinical signs of inflammation of the periodontium and the detection of periodontopathogenic bacteria species. 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