{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:32:08Z","timestamp":1760920328759,"version":"build-2065373602"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007270","name":"University of Michigan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Infection is a risk factor for preterm birth. This study was conducted in the field and addressed the link between periodontal pathogens measured with the benzoyl\u2010DL\u2010arginine\u2010naphthylamide (BANA) test and preterm birth.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This prospective study was performed in Changhua, Taiwan. Periodontal examinations included the plaque index, papillary bleeding scores, and measurement of the BANA enzyme in plaque samples at the second and third trimesters. Independent variables included maternal demographic characteristics, previous pregnancy histories, risk factors, plaque and gingivitis scores, and current pregnancy outcomes.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> There were 19 (7%) preterm deliveries among the 268 subjects. A history of a previous preterm birth and low birth weight, frequency of prenatal visits, preterm uterine contractions, antepartum hemorrhages, placenta previae, and preterm premature rupture of membranes were significantly related to preterm birth (<jats:italic>P<\/jats:italic> = 0.035, 0.027, &lt;0.001, 0.025, 0.006, 0.014, and &lt;0.001, respectively). Maternal weight gain was higher with a normal term delivery (<jats:italic>P<\/jats:italic> = 0.003). Multivariable logistic regression analyses showed that the number of BANA\u2010infected sites in the third trimester (odds ratio [OR]: 5.89; 95% confidence interval [CI]: 1.5 to 31.6), maternal weight gain (OR: 0.78; 95% CI: 0.65 to 0.91), antepartum hemorrhages (OR: 10.0; 95% CI: 2.2 to 46.9), and preterm premature rupture of membranes (OR: 12.6; 95% CI: 3.97 to 42.71) had significant influences on preterm\u2010birth outcomes.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> BANA\u2010positive plaque in the third trimester was associated with preterm births after controlling for other risk factors. The BANA test can be used to screen pregnant women at chairside and\/or bedside to apply suitable intervention tactics.<\/jats:p>","DOI":"10.1902\/jop.2010.090532","type":"journal-article","created":{"date-parts":[[2010,4,12]],"date-time":"2010-04-12T11:10:40Z","timestamp":1271070640000},"page":"982-991","source":"Crossref","is-referenced-by-count":9,"title":["Periodontal Disease Activity Measured by the Benzoyl\u2010DL\u2010Arginine\u2010Naphthylamide Test Is Associated With Preterm Births"],"prefix":"10.1002","volume":"81","author":[{"given":"Hui\u2010Chen","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen\u2010Tsai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen B.","family":"Welch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter J.","family":"Loesche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_7_3_1","first-page":"227","article-title":"Endotoxin stimulates prostaglandin E2 production by human amnion","volume":"71","author":"Romero R","year":"1988","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005183422007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.4.727-752.2001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1998.3.1.233"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060201"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.12.1764"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060368"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060362"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1986.tb00322.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1987.58.4.266"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.2.427-433.1992"},{"key":"e_1_2_7_15_1","article-title":"The ability of the BANA Test to detect different levels of P. gingivalis, T. denticola and T. forsythia","author":"de Andrade JA","year":"2010","journal-title":"Brazilian Oral Research"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0b013e328012359a"},{"key":"e_1_2_7_17_1","first-page":"77","article-title":"Relationship between clinical probing depth and reactivity to the BANA test of samples of subgingival microbiota from patients with periodontitis","volume":"9","author":"Grisi MF","year":"1998","journal-title":"Braz Dent J"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050449"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345900690101301"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.260209.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345790580120905"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115930"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.JNR.0000347586.08328.d6"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2006.0089"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/80.1.27"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/78.3.691"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1109\/TAC.1974.1100705"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01222.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790010701"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070655"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.12.002"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070554"},{"key":"e_1_2_7_34_1","first-page":"1","volume-title":"The prevelance of members of the \u201cred complex\u201d in pregnant women as revealed by PCR and BANA hydrolysis. 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