{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:29:25Z","timestamp":1791268165307,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Prostate\u2010specific antigen (PSA) is an inflammatory marker produced by the epithelial cells of the prostate acini. In the presence of inflammation or malignancy of the prostate, PSA levels are \u22654 ng\/ml. This preliminary study was conducted to evaluate any association between periodontitis and PSA levels in chronic prostatitis patients.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Thirty\u2010five subjects who underwent prostate biopsy because of abnormal findings on digital rectal examination or elevated PSA (\u22654 ng\/ml) participated in the study. Plaque and gingival indices, bleeding on probing, probing depth, and clinical attachment level (CAL) were determined. Two\u2010sided independent sample <jats:italic>t<\/jats:italic> tests assessed any significant differences in the PSA levels between and among the groups of prostatitis and periodontitis.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Mean PSA levels were significantly higher (<jats:italic>P<\/jats:italic> = 0.04) in subjects with moderate\/severe prostate inflammation than those with none\/mild (8.8 \u00b1 5.8 versus 5.7 \u00b1 3.1 ng\/ml). Subjects with CAL \u22652.7 mm had higher but not statistically significant PSA levels than those with CAL &lt;2.7 mm (7.7 \u00b1 5.2 versus 5.7 \u00b1 3.2 ng\/ml), respectively. Individuals having both moderate\/severe prostatitis and CAL \u22652.7 mm (10.8 \u00b1 7 ng\/ml) had significantly higher mean PSA levels (<jats:italic>P<\/jats:italic> = 0.05) than those with neither condition (5.6 \u00b1 3.7 ng\/ml) nor only CAL \u22652.7 mm (5.7 \u00b1 2.4 ng\/ml) or moderate\/severe prostatitis (6 \u00b1 1.9 ng\/ml).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Subjects having comorbidity of CAL \u22652.7 mm and moderate\/severe prostatitis have higher PSA levels than those with either condition alone.<\/jats:p>","DOI":"10.1902\/jop.2010.090646","type":"journal-article","created":{"date-parts":[[2010,4,9]],"date-time":"2010-04-09T11:43:23Z","timestamp":1270813403000},"page":"864-869","source":"Crossref","is-referenced-by-count":42,"title":["Association Between Periodontal Disease and Prostate\u2010Specific Antigen Levels in Chronic Prostatitis 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