{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:32:46Z","timestamp":1760920366343,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004375","name":"Tel Aviv University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004375","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Peripheral giant cell granuloma (PGCG) is a reactive hyperplastic lesion involving the gingiva or alveolar mucosa consisting of proliferating endothelial cells, a rich capillary bed, chronic inflammatory cells, fibroblasts, and giant cells. After complete clinical removal of PGCG recurrence occurs in about 10% of cases, and may result in an esthetic and functional soft tissue defect. This report describes a surgical procedure involving complete removal of a gingival PGCG in the maxillary esthetic zone and immediate tissue restoration achieving complete gingival augmentation.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A 15\u2010year\u2010old female presented with a red, nodular, asymptomatic lesion, approximately 3.5 mm in diameter, located above the maxillary left lateral incisor. The lesion was excised down to the underlying root resulting in a 6 \u00d7 5\u2010mm mucogingival dehiscence defect. Corrective surgery included a subepithelial connective tissue graft peripherally covered by the surrounding gingiva and stabilized by 5\/0 resorbable sutures.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Healing was uneventful, resulting in healthy and esthetic gingiva. Microscopic examination of the biopsy specimen was consistent with the diagnosis of PGCG.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> PGCG may follow an aggressive course, sometimes requiring preemptive surgical intervention. Grafting a subepithelial connective tissue graft peripherally covered by the surrounding gingiva, without raising a gingival flap, successfully eliminated the gingival defect. The free gingival margin of the neighboring teeth and the mucogingival junction remained unchanged.<\/jats:p>","DOI":"10.1902\/jop.2010.090674","type":"journal-article","created":{"date-parts":[[2010,3,29]],"date-time":"2010-03-29T12:39:13Z","timestamp":1269866353000},"page":"1092-1098","source":"Crossref","is-referenced-by-count":5,"title":["Esthetic Treatment of Peripheral Giant Cell Granuloma Using a Subepithelial Connective Tissue Graft and a Split\u2010Thickness Pouch Technique"],"prefix":"10.1002","volume":"81","author":[{"given":"Ron","family":"Lev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ofer","family":"Moses","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Holtzclaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haim","family":"Tal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(88)80158-9"},{"key":"e_1_2_6_3_1","first-page":"311","article-title":"Inflammatory hyperplasias of the oral mucosa","volume":"58","author":"Priddy RW","year":"1992","journal-title":"J Can Dent Assoc"},{"key":"e_1_2_6_4_1","first-page":"437","volume-title":"Oral & Maxillofacial Pathology","author":"Neville BW","year":"2002"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1980.51.11.655"},{"key":"e_1_2_6_6_1","first-page":"130","volume-title":"Differential Diagnosis of Oral and Maxillofacial Lesions","author":"Wood NK","year":"1997"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197210)30:4<1119::AID-CNCR2820300433>3.0.CO;2-Z"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(53)90151-0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1972.tb02120.x"},{"key":"e_1_2_6_10_1","first-page":"110","article-title":"Giant cell reparative granuloma (peripheral): Report of 50 cases","volume":"29","author":"Bhaskar SN","year":"1971","journal-title":"J Oral Surg"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1977.48.2.101"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1995.tb00152.x"},{"key":"e_1_2_6_13_1","first-page":"787","article-title":"Peripheral giant cell granuloma: Review of 720 cases","volume":"27","author":"Giansanti JS","year":"1969","journal-title":"J Oral Surg"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1995.tb00151.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1954.0138"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.3.487"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1970.41.1.41"},{"key":"e_1_2_6_18_1","first-page":"606","article-title":"Oral giant cell granulomas: A clinical and histological study of 129 new cases","volume":"81","author":"Andersen L","year":"1973","journal-title":"Acta Pathol Microbiol Scand A"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016358309162306"},{"key":"e_1_2_6_20_1","first-page":"103","article-title":"Reactive gingival lesions: A retrospective study of 2,439 cases","volume":"38","author":"Zhang W","year":"2007","journal-title":"Quintessence Int"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.12.022"},{"key":"e_1_2_6_22_1","first-page":"232","article-title":"Peripheral giant cell granuloma: A potentially aggressive lesion in children","volume":"22","author":"Flaitz CM","year":"2000","journal-title":"Pediatr Dent"},{"key":"e_1_2_6_23_1","first-page":"114","volume-title":"Oral Pathology: Clinical Pathological Correlations","author":"Regezi JA","year":"1999"},{"key":"e_1_2_6_24_1","first-page":"53","article-title":"Peripheral giant cell granuloma. 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