{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:43:11Z","timestamp":1773150191608,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Rheumatoid arthritis (RA) and periodontitis are common chronic inflammatory conditions and share many pathologic features. A similar profile of cytokines is involved in the pathogenesis of the two diseases. The relationship between the disease activity of RA and the periodontal condition remains unclear. This study examines whether the disease activity of RA affects serum cytokine and periodontal profiles.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The study subjects consisted of 84 Japanese adults with RA and 22 race\u2010matched control individuals. After periodontal and rheumatologic examination, the disease activity of RA was determined with the Disease Activity Score including 28 joints using C\u2010reactive protein (DAS28\u2010CRP). Serum levels of cytokines including interleukin (IL)\u20101\u03b2, IL\u20106, IL\u201012, IL\u201012 p40, IL\u201018, and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) were determined by an enzyme\u2010linked immunosorbent assay. High\u2010sensitive CRP was also measured with a latex particle\u2010enhanced nephelometric method.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Of 84 patients with RA, 28 and 56 patients exhibited low and moderate to high disease activity, respectively. Serum levels of IL\u20106, TNF\u2010\u03b1, and CRP were significantly different between the two groups (<jats:italic>P<\/jats:italic> &lt;0.05). Additionally, a significant correlation was observed between DAS28\u2010CRP and percentage of sites with bleeding on probing (BOP) (<jats:italic>P<\/jats:italic> = 0.008) and between serum TNF\u2010\u03b1 levels and percentage of sites with BOP (<jats:italic>P<\/jats:italic> = 0.01) in 56 patients with RA with moderate to high activity.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> These results suggest that the disease activity of RA correlated with serum levels of IL\u20106, TNF\u2010\u03b1, and CRP, and it might influence BOP in the patients with moderate to high disease activity.<\/jats:p>","DOI":"10.1902\/jop.2010.090688","type":"journal-article","created":{"date-parts":[[2010,4,9]],"date-time":"2010-04-09T11:43:23Z","timestamp":1270813403000},"page":"650-657","source":"Crossref","is-referenced-by-count":53,"title":["Serum Cytokine and Periodontal Profiles in Relation to Disease Activity of Rheumatoid Arthritis in Japanese Adults"],"prefix":"10.1002","volume":"81","author":[{"given":"Tetsuo","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asami","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouji","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromasa","family":"Yoshie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,5]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1650","article-title":"Adult periodontitis as a model for rheumatoid arthritis (with emphasis on treatment strategies)","volume":"26","author":"Greenwald RA","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00371.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.28"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780401221"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027004267.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.6.779"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070501"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00689.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e3180690616"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080447"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.14.1.397"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.11.1013"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-S.2066"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.12.2276"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070616"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.1.75"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2006.00292.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.423"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.16.1.495"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070136"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080573"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060135"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_7_25_1","unstructured":"Department of Rheumatology University Medical Center Nijmegen\u2010The Netherlands.DAS\u2010score.nl:home of the DAS. 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