{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:04:38Z","timestamp":1790910278378,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Previous studies suggest that periodontitis is closely related to obesity and metabolic syndrome. Leptin, a pleiotrophic hormone produced by adipose tissue, has been reported to be related to periodontitis. This study investigates the effects of periodontal treatment on the serum levels of leptin and other cytokines in patients with chronic periodontitis (CP).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Serum samples were taken from 33 CP patients (22 non\u2010smokers, 11 smokers) and 18 healthy subjects. The serum leptin, adiponectin, tumor necrosis factor\u2010\u03b1, interleukin (IL)\u20106, and C\u2010reactive protein (CRP) levels were measured before and after non\u2010surgical periodontal treatment.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Significant differences between healthy and CP patients were found in serum leptin, IL\u20106, and CRP levels (<jats:italic>P<\/jats:italic> = 0.0018, <jats:italic>P<\/jats:italic> = 0.0064, and <jats:italic>P<\/jats:italic> = 0.0095, respectively). The serum leptin level was associated with mean probing depth, mean clinical attachment level, mean alveolar bone loss, and body mass index. There were significant associations between serum leptin levels and IL\u20106 and CRP levels. After non\u2010surgical periodontal treatment, serum leptin, IL\u20106, and CRP levels were significantly decreased (mean \u00b1 SD before and after, <jats:italic>P<\/jats:italic> value, respectively: leptin, 8.02 \u00b1 5.5, 7.10 \u00b1 4.4, <jats:italic>P<\/jats:italic> = 0.015; IL\u20106, 1.73 \u00b1 1.02, 1.36 \u00b1 0.73, <jats:italic>P<\/jats:italic> = 0.048; and CRP, 802.0 \u00b1 1065, 491.2 \u00b1 479.3, <jats:italic>P<\/jats:italic> = 0.047).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Periodontal treatment is effective in reducing serum leptin, IL\u20106, and CRP levels. The results suggest that leptin, IL\u20106, and CRP could be mediating factors that connect metabolic syndrome and periodontitis.<\/jats:p>","DOI":"10.1902\/jop.2010.090741","type":"journal-article","created":{"date-parts":[[2010,4,7]],"date-time":"2010-04-07T00:14:25Z","timestamp":1270599265000},"page":"1118-1123","source":"Crossref","is-referenced-by-count":155,"title":["The Effect of Periodontal Treatment on Serum Leptin, Interleukin\u20106, and C\u2010Reactive Protein"],"prefix":"10.1002","volume":"81","author":[{"given":"Yasuko","family":"Shimada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutaka","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuyo","family":"Ikezawa\u2010Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Sugita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromasa","family":"Yoshie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66378-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708600503"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00186.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/372425a0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.6.3137"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0431rev"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2007.09.004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.10.952"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.046540"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01078.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2006.00948.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050277"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2007.00207.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01331.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0702.104279"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.72.9.1254"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2004.00772.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2009.01209.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00832.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01317.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060217"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1999.1490"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1372"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10156"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01049-8"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/hh0901.090975"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007383200"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2010.090741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:35:01Z","timestamp":1760880901000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2010.090741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["10.1902\/jop.2010.090741"],"URL":"https:\/\/doi.org\/10.1902\/jop.2010.090741","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}