{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T14:26:12Z","timestamp":1773498372464,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Several anti\u2010inflammatory drugs have been used to reduce pain and discomfort after periodontal surgeries. This study evaluates the efficacy of using etoricoxib and dexamethasone for pain prevention after open\u2010flap debridement surgery.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> For this prospective, double\u2010masked, crossover, placebo\u2010controlled, randomized clinical trial, open\u2010flap debridement surgeries were performed on 15 patients (eight males and seven females, age range 20 to 56 years: mean age \u00b1 SD: 40 \u00b1 9.7 years) who presented with chronic periodontitis after non\u2010surgical periodontal therapy at three quadrants. Each patient underwent three surgical procedures at intervals of 30 days and received one of the following premedication protocols 1\u2010hour before surgery: group 1 = placebo, group 2 = 8 mg dexamethasone, and group 3 = 120 mg etoricoxib. Rescue medication (750 mg acetaminophen) was given to each patient who was instructed to take it when necessary. Pain intensity and discomfort were evaluated by a 101\u2010point numeric rate scale and a four\u2010point verbal rate scale, respectively, hourly for the first 8 hours after surgery and three times a day on the following 3 days.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The results demonstrate that groups 2 and 3 present reduced postoperative pain\u2010intensity levels compared to group 1. There were statistically significant differences at the 4, 5, 6, 7, and 8 hour\u2010periods after surgery (Friedman test; <jats:italic>P<\/jats:italic> &lt;0.05). Furthermore, rescue\u2010medication intake was significantly lower for groups 2 and 3 than for group 1 (analysis of variance; <jats:italic>P<\/jats:italic> &lt;0.02).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The adoption of a preemptive medication protocol using etoricoxib or dexamethasone may be considered effective for pain and discomfort prevention after open\u2010flap debridement surgeries.<\/jats:p>","DOI":"10.1902\/jop.2010.100059","type":"journal-article","created":{"date-parts":[[2010,4,2]],"date-time":"2010-04-02T13:01:13Z","timestamp":1270213273000},"page":"1153-1160","source":"Crossref","is-referenced-by-count":25,"title":["Preemptive Dexamethasone and Etoricoxib for Pain and Discomfort Prevention After Periodontal Surgery: A Double\u2010Masked, Crossover, Controlled Clinical Trial"],"prefix":"10.1002","volume":"81","author":[{"given":"Joao 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