{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T22:36:42Z","timestamp":1787524602524,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Hyperoxaluria is a metabolic disease with excessive urinary oxalate excretion that can be primary or secondary. Hyperoxaluria can result in chronic renal disease and renal failure. Calcium oxalate crystals can be deposited in oral tissues, and the disease can be associated with severe periodontitis and tooth loss.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The periodontal condition of a 38\u2010year\u2010old patient with a diagnosis of hyperoxaluria and end\u2010stage renal disease is presented. The patient's periodontal status was monitored over a period of several weeks, and extracted teeth were submitted for histopathologic evaluation.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The patient was diagnosed with generalized severe periodontitis and external root resorption. Initial periodontal treatment consisting of oral\u2010hygiene instructions and scaling and root planing was performed. However, despite an initial decrease of soft tissue inflammation, the patient's periodontal condition deteriorated, and eventually, all teeth had to be extracted. The deposition of calcium oxalate crystals in the periodontal tissues was confirmed histologically.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Long\u2010standing hyperoxaluria can be associated with severe periodontitis and external root resorption resulting in tooth loss. The pathogenetic mechanisms of hard tissue destruction are still unclear.<\/jats:p>","DOI":"10.1902\/jop.2010.100092","type":"journal-article","created":{"date-parts":[[2010,6,9]],"date-time":"2010-06-09T14:02:18Z","timestamp":1276092138000},"page":"1497-1504","source":"Crossref","is-referenced-by-count":13,"title":["Severe Periodontitis in a Patient With Hyperoxaluria and Oxalosis: A Case Report and Review of the Literature"],"prefix":"10.1002","volume":"81","author":[{"given":"Vassilios","family":"Panis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos I.","family":"Tosios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Gagari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrence J.","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros D.","family":"Damoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411970080010401"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1291986"},{"key":"e_1_2_6_4_1","first-page":"337","volume-title":"Primer on Kidney Diseases","author":"Greenberg A","year":"1998"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(82)90303-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(86)90374-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1989.tb01558.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(73)90007-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(82)90302-4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1989.60.5.271"},{"key":"e_1_2_6_11_1","first-page":"260","article-title":"Primary hyperoxaluria in a pediatric dental patient: Case report","volume":"14","author":"Rahima MM","year":"1992","journal-title":"Pediatr Dent"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_6_14_1","unstructured":"MillerSC.Textbook of Periodontia (Oral Medicine).The Blakiston Company Philadelphia;1950:125."},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.7.658"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2008.0346"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508400301"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2007.01430.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(03)00381-0"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9629(15)40516-6"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.3.337"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.60"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002400100193"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2009.98"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2010.100092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:31:33Z","timestamp":1760873493000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2010.100092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["10.1902\/jop.2010.100092"],"URL":"https:\/\/doi.org\/10.1902\/jop.2010.100092","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}