{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:39:31Z","timestamp":1785537571771,"version":"3.56.0"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007109","name":"Universit\u00e0 degli Studi di Ferrara","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007109","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The single flap approach (SFA) is a minimally invasive procedure designed for periodontal reconstructive procedures of intraosseous periodontal defects characterized by a dominant unilateral, buccal or oral, extension. This study evaluates the adjunctive effect of guided tissue regeneration (GTR) combined with a hydroxyapatite (HA) biomaterial in the management of intraosseous periodontal defects accessed with SFA compared to SFA alone.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty\u2010four intraosseous defects (in 24 patients) were randomly allocated to treatment with SFA or SFA + HA\/GTR. Clinical outcomes were assessed 6 months post\u2010surgery.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Five sites in the SFA + HA\/GTR group showed incomplete closure at week 2, which resolved spontaneously. There were no statistically significant or clinically meaningful differences in mean (\u00b1SD) clinical attachment gain (4.7 \u00b1 2.5 versus 4.4 \u00b1 1.5 mm), probing depth reduction (5.3 \u00b1 2.4 versus 5.3 \u00b1 1.5 mm), and gingival recession increase (0.4 \u00b1 1.4 versus 0.8 \u00b1 0.8 mm) between the SFA + HA\/GTR and SFA groups.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> SFA with and without HA\/GTR seems to be a valuable minimally invasive approach in the treatment of deep intraosseous periodontal defects. Under the present experimental conditions, the additional HA\/GTR protocol offers no significant adjunctive effect.<\/jats:p>","DOI":"10.1902\/jop.2010.100113","type":"journal-article","created":{"date-parts":[[2010,6,9]],"date-time":"2010-06-09T14:02:18Z","timestamp":1276092138000},"page":"1256-1263","source":"Crossref","is-referenced-by-count":105,"title":["Single Flap Approach With and Without Guided Tissue Regeneration and a Hydroxyapatite Biomaterial in the Management of Intraosseous Periodontal Defects"],"prefix":"10.1002","volume":"81","author":[{"given":"Leonardo","family":"Trombelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Simonelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Pramstraller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf 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