{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:36:06Z","timestamp":1777480566328,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this study is to evaluate the levels of osteoclastogenesis\u2010related factors (soluble receptor activator of nuclear factor\u2010kappa B ligand [sRANKL] and osteoprotegerin [OPG]) in gingival crevicular fluid (GCF) from subjects with poorly and well\u2010controlled type 2 diabetes and chronic periodontitis before and after periodontal therapy.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Eighteen subjects with well\u2010controlled diabetes (glycated hemoglobin [HbA1c] levels \u22648%) and 20 subjects with poorly controlled diabetes (HbA1c levels &gt;8%) were enrolled in this study. All subjects were submitted to non\u2010surgical periodontal therapy. GCF sampling and clinical periodontal parameters were assessed at baseline and 3 and 6 months post\u2010therapy. Total amounts and concentrations of sRANKL and OPG in GCF were analyzed by enzyme\u2010linked immunosorbent assay (ELISA).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Total amounts and concentrations of sRANKL and RANKL\/OPG ratios were higher in poorly controlled subjects than in well\u2010controlled subjects at baseline and 3 and 6 months post\u2010therapy (<jats:italic>P<\/jats:italic> &lt;0.05). In addition, RANKL\/OPG ratios decreased in well\u2010controlled subjects (<jats:italic>P<\/jats:italic> &lt;0.05) but not in poorly controlled subjects (<jats:italic>P<\/jats:italic> &gt;0.05) at 3 months post\u2010therapy. Almost all clinical parameters improved significantly for both groups post\u2010treatment (<jats:italic>P<\/jats:italic> &lt;0.05).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> RANKL\/OPG ratios in untreated and treated periodontitis sites may be negatively influenced by poor glycemic control in subjects with type 2 diabetes.<\/jats:p>","DOI":"10.1902\/jop.2010.100125","type":"journal-article","created":{"date-parts":[[2010,5,17]],"date-time":"2010-05-17T12:36:38Z","timestamp":1274099798000},"page":"1455-1465","source":"Crossref","is-referenced-by-count":72,"title":["Receptor Activator of Nuclear Factor\u2010Kappa B Ligand\/Osteoprotegerin Ratio in Sites of Chronic Periodontitis of Subjects With Poorly and Well\u2010Controlled Type 2 Diabetes"],"prefix":"10.1002","volume":"81","author":[{"given":"Vanessa Renata","family":"Santos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jadson Almeida","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago Eduardo Dias","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta Ferreira","family":"Bastos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciene Cristina","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamil Awad","family":"Shibli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poliana Mendes","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,10]]},"reference":[{"key":"e_1_2_7_2_1","article-title":"Advances in the treatment of type 2 diabetes mellitus","author":"Israili ZH","year":"2009","journal-title":"Am J Ther"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070442"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01282.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2002.300304.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.01032.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080233"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00327.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-S.2033"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12178-009-9046-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.00615.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300216"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.12.1586"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2006.00883.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01061.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2006.00946.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2006.01348.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01440.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.12.1736"},{"key":"e_1_2_7_21_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J","year":"1975","journal-title":"Int Dent J"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060398"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2008.08.007"},{"key":"e_1_2_7_24_1","first-page":"17","article-title":"Expression of RANKL and OPG mRNA in periodontal disease: Possible involvement in bone destruction","volume":"11","author":"Liu D","year":"2003","journal-title":"Int J Mol Med"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.5.1477"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.9.1260"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2006.03.017"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)42138-2"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2000.2230104.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8942"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.090148"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.1.2"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3379"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22192"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.12.107"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813450701602523"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00219.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02417.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090030"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050084"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01127.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.260909.x"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01289.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01119.x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508401212"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2009.06.002"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090106"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070073"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2010.100125","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1902\/jop.2010.100125","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2010.100125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:31:53Z","timestamp":1760873513000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2010.100125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":47,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["10.1902\/jop.2010.100125"],"URL":"https:\/\/doi.org\/10.1902\/jop.2010.100125","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}