{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T19:32:15Z","timestamp":1785871935260,"version":"3.56.0"},"reference-count":51,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Limited orthodontics are shown to be effective in the correction of infrabony defects. Studies have also demonstrated the efficacy of using enamel matrix derivative (EMD) with demineralized freeze\u2010dried bone allograft (DFDBA) to treat infrabony defects. This study aims to compare the clinical efficacy of limited orthodontics combined with EMD\/DFDBA in the treatment of 2\u2010 or 3\u2010wall infrabony defects.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A randomized, parallel clinical trial was conducted in a private periodontal practice (Tokyo, Japan) between April 2004 and October 2008. Treatment period was 1 year with a 1\u2010year follow\u2010up. Forty\u2010seven randomized patients, mean age of 53 \u00b1 10.7 years, were allocated into two intervention groups: ortho\/EMD\/DFDBA (n = 24) and EMD\/DFDBA (n = 23). Each patient had either a 2\u2010 or 3\u2010wall infrabony defect of \u22656 mm deep. Probing depth and clinical attachment level were measured at baseline and 1 year. The primary outcome measure was absolute change in probing depth and clinical attachment level from baseline to 1\u2010year follow\u2010up. The secondary outcome measure was absolute change in open probing attachment level gain and percentage defect resolution from baseline to 6\u2010month reentry surgery. Infrabony defects were surgically treated with EMD and DFDBA 4 weeks before application of orthodontic extrusive forces. Reentry surgeries were performed at 6 months after initial surgery.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Forty\u2010seven patients were analyzed. Both treatment groups showed a significant improvement from baseline with no significant difference between the groups except for the 2\u2010wall defects. The ortho\/EMD\/DFDBA group had statistically significant open probing attachment level gain (95% confidence level, 3.18 to 4.36; <jats:italic>P<\/jats:italic> = 0.036) compared to the EMD\/DFDBA group (95% confidence level, 2.26 to 3.24) in 2\u2010wall defects.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Although both treatment modalities were effective in managing 2\u2010 or 3\u2010wall infrabony defects, limited orthodontics provided an additional benefit to EMD\/DFDBA in 2\u2010wall defects.<\/jats:p>","DOI":"10.1902\/jop.2010.100127","type":"journal-article","created":{"date-parts":[[2010,7,14]],"date-time":"2010-07-14T18:37:04Z","timestamp":1279132624000},"page":"1734-1742","source":"Crossref","is-referenced-by-count":40,"title":["Periodontal Regeneration With or Without Limited Orthodontics for the Treatment of 2\u2010 or 3\u2010Wall Infrabony 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