{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T21:51:12Z","timestamp":1771537872433,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The purpose of this study is to compare the healing of deep, non\u2010contained intrabony defects (i.e., with a \u226580% 1\u2010wall component and a residual 2\u2010 to 3\u2010wall component in the most apical part) treated with either an enamel matrix derivative (EMD) or guided tissue regeneration (GTR) after 12 months.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> In this randomized, controlled clinical trial, 40 subjects with 40 defects affecting single\u2010rooted teeth were treated. The defects were treated with EMD alone or with a non\u2010resorbable titanium\u2010reinforced membrane. No grafting materials were used. At baseline and after 12 months, clinical parameters including probing depths (PDs) and clinical attachment levels (CAL) were recorded. The difference in CAL gain was the primary outcome.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> At baseline, the intrabony component of the defects amounted to 8.5 \u00b1 2.2 mm at EMD\u2010treated sites and 8.6 \u00b1 1.7 mm at GTR\u2010treated sites (<jats:italic>P<\/jats:italic> = 0.47). The mean CAL gain at sites treated with GTR was significantly greater (<jats:italic>P<\/jats:italic> &lt;0.001) than that at sites treated with EMD (4.1 \u00b1 1.4 mm versus 2.4 \u00b1 2.2 mm, respectively). GTR therapy, compared to EMD application alone, significantly (<jats:italic>P<\/jats:italic> = 0.01) increased the probability of CAL gain \u22654 mm (79.2% versus 11.3%, respectively) and significantly (<jats:italic>P<\/jats:italic> = 0.01) decreased the probability of residual PDs \u22656 mm (3% versus 79.3%, respectively).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Although the outcomes of open\u2010flap debridement alone were not investigated, the application of EMD alone appeared to yield less PD reduction and CAL gain compared to GTR therapy in the treatment of deep, non\u2010contained intrabony defects.<\/jats:p>","DOI":"10.1902\/jop.2010.100144","type":"journal-article","created":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T19:55:09Z","timestamp":1283370909000},"page":"62-71","source":"Crossref","is-referenced-by-count":75,"title":["Clinical Outcomes After Treatment of Non\u2010Contained Intrabony Defects With Enamel Matrix Derivative or Guided Tissue 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