{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:27:22Z","timestamp":1792592842553,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002657","name":"Istanbul \u00dcniversitesi","doi-asserted-by":"publisher","award":["T\u2010969\/06102006"],"award-info":[{"award-number":["T\u2010969\/06102006"]}],"id":[{"id":"10.13039\/501100002657","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this study is to evaluate the effect of low\u2010level laser therapy (LLLT) as an adjunct to non\u2010surgical periodontal therapy of smoking and non\u2010smoking patients with moderate to advanced chronic periodontitis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> All 36 systemically healthy patients who were included in the study initially received non\u2010surgical periodontal therapy. The LLLT group (n = 18) received GaAlAs diode laser therapy as an adjunct to non\u2010surgical periodontal therapy. A diode laser with a wavelength of 808 nm was used for the LLLT. Energy density of 4 J\/cm<jats:sup>2<\/jats:sup> was applied to the gingival surface after periodontal treatment on the first, second, and seventh days. Each of the LLLT and control groups was divided into two groups as smoking and non\u2010smoking patients to investigate the effect of smoking on treatment. Gingival crevicular fluid samples were collected from all patients and clinical parameters were recorded on baseline, the first, third, and sixth months after treatment. Matrix metalloproteinase\u20101, tissue inhibitor matrix metalloproteinase\u20101, transforming growth factor\u2010\u03b21, and basic\u2010fibroblast growth factor levels in the collected gingival crevicular fluid were measured.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The primary outcome variable in this study was change in gingival bleeding and inflammation. At all time points, the LLLT group showed significantly more improvement in sulcus bleeding index (SBI), clinical attachment level, and probing depth (PD) levels compared to the control group (<jats:italic>P<\/jats:italic> &lt;0.001). There were clinically significant improvements in the laser\u2010applied smokers' PD and SBI levels compared to smokers to whom a laser was not applied, between the baseline and all time points (<jats:italic>P<\/jats:italic> &lt;0.001) (SBI score: control group 1.12, LLLT group 1.49; PD: control group 1.21 mm, LLLT group 1.46 mm, between baseline and 6 months). Transforming growth factor\u2010\u03b21 levels and the ratio of matrix metalloproteinase\u20101 to tissue inhibitor matrix metalloproteinase\u20101 decreased significantly in both groups at 1, 3, and 6 months after periodontal therapy (<jats:italic>P<\/jats:italic> &lt;0.001). Basic\u2010fibroblast growth factor levels significantly decreased in both groups in the first month after the treatment, then increased in the third and sixth months (<jats:italic>P<\/jats:italic> &lt;0.005). No marker level change showed significant differences between the groups (<jats:italic>P<\/jats:italic> &lt;0.05).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> LLLT as an adjunctive therapy to non\u2010surgical periodontal treatment improves periodontal healing.<\/jats:p>","DOI":"10.1902\/jop.2010.100195","type":"journal-article","created":{"date-parts":[[2010,10,8]],"date-time":"2010-10-08T14:04:55Z","timestamp":1286546695000},"page":"481-488","source":"Crossref","is-referenced-by-count":105,"title":["The Effect of Low\u2010Level Laser Therapy as an Adjunct to Non\u2010Surgical Periodontal 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