{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:22:51Z","timestamp":1761675771165,"version":"build-2065373602"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Endosseous implants coated with recombinant human bone morphogenetic protein\u20102 (rhBMP\u20102) in a laboratory bench setting and air\u2010dried induce relevant bone formation but also resident bone remodeling. Thus, the objective of this study is to evaluate the effect of implants fully or partially coated with rhBMP\u20102 and vacuum\u2010dried using an industrial process on local bone formation and resident bone remodeling.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twelve male adult Hound Labrador mongrel dogs were used. Critical\u2010size, supraalveolar, peri\u2010implant defects received titanium porous oxide surface implants coated in their most coronal aspect with rhBMP\u20102 (coronal\u2010load, six animals), or by immersion of the entire implant in a rhBMP\u20102 solution (soak\u2010load, six animals) for a total of 30 \u03bcg rhBMP\u20102 per implant. All implants were vacuum\u2010dried. The animals were sacrificed at 8 weeks for histometric evaluation.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Clinical healing was unremarkable. Bone formation was not significantly affected by the rhBMP\u20102 application protocol. New bone height and area averaged (\u00b1 SE) 3.2 \u00b1 0.5 versus 3.6 \u00b1 0.3 mm, and 2.3 \u00b1 0.5 versus 2.6 \u00b1 0.8 mm<jats:sup>2<\/jats:sup> for coronal\u2010load and soak\u2010load implants, respectively (<jats:italic>P<\/jats:italic> &gt;0.05). The corresponding bone density and bone\u2013implant contact registrations averaged 46.7% \u00b1 5.8% versus 31.6% \u00b1 4.4%, and 28% \u00b1 5.6% versus 36.9% \u00b1 3.4% (<jats:italic>P<\/jats:italic> &gt;0.05). In contrast, resident bone remodeling was significantly influenced by the rhBMP\u20102 application protocol. Peri\u2010implant bone density averaged 72.2% \u00b1 2.1% for coronal\u2010load versus 60.6% \u00b1 4.7% for soak\u2010load implants (<jats:italic>P<\/jats:italic> &lt;0.05); the corresponding bone\u2013implant contact averaged 70.7% \u00b1 6.1% versus 47.2% \u00b1 6.0% (<jats:italic>P<\/jats:italic> &lt;0.05).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Local application of rhBMP\u20102 and vacuum\u2010drying using industrial process seems to be a viable technology to manufacture implants that support local bone formation and osseointegration. Coronal\u2010load implants obviate resident bone remodeling without compromising local bone formation.<\/jats:p>","DOI":"10.1902\/jop.2010.100220","type":"journal-article","created":{"date-parts":[[2010,7,14]],"date-time":"2010-07-14T18:37:04Z","timestamp":1279132624000},"page":"1839-1849","source":"Crossref","is-referenced-by-count":15,"title":["Evaluation of Implants Coated With Recombinant Human Bone Morphogenetic Protein\u20102 and Vacuum\u2010Dried Using the Critical\u2010Size Supraalveolar Peri\u2010Implant Defect Model in Dogs"],"prefix":"10.1002","volume":"81","author":[{"given":"John F.","family":"Decker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaebum","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo Alberto","family":"Cortella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Polimeni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Rohrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Wozney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiano","family":"Susin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf M.E.","family":"Wikesj\u00f6","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-6343.2009.01461.x"},{"key":"e_1_2_7_3_1","first-page":"5","article-title":"Properties of a new porous oxide surface on titanium implants","volume":"1","author":"Hall J","year":"2000","journal-title":"Appl Osseoint Res"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01064.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01318.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01322.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01321.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01554.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01579.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01567.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01308.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00985.x"},{"first-page":"273","volume-title":"Stability of Protein Pharmaceuticals. 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