{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:50:01Z","timestamp":1787503801591,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Eucalyptus extracts were found to possess an antibacterial activity against some oral pathogens that produce oral malodor compounds in vitro; however, the clinical effects with respect to oral malodor in humans remain unproven. In the present investigation, a randomized clinical study was designed to test the hypothesis that eucalyptus\u2010extract chewing gum can reduce oral malodor in the general adult population.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Subjects were randomly assigned to the following three groups: a high\u2010concentration (0.6% eucalyptus extract) group (n = 32), a low\u2010concentration (0.4% eucalyptus extract) group (n = 32), and a placebo group (n = 33). The intake period was 12 weeks. The organoleptic score, level of volatile sulfur compounds (VSCs), and tongue\u2010coating score were recorded at baseline and 4, 8, 12, and 14 weeks. Treatment\u2010to\u2010time interactions among groups were evaluated by repeated\u2010measures analysis of variance (ANOVA) followed by the Games\u2010Howell pairwise comparison test.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Relative to baseline readings, significant reductions in clinical parameters, including organoleptic and tongue\u2010coating scores in the high\u2010 and\/or low\u2010concentration groups, occurred at 4, 8, 12, and 14 weeks (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). In addition, group\u2013time interactions revealed significant reductions in the organoleptic score, VSCs, and tongue\u2010coating score in both concentration groups compared to the placebo group (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Eucalyptus\u2010extract chewing gum had long\u2010term effects on the olganoleptic score, levels of VSCs, and tongue\u2010coating score. These findings suggest that eucalyptus\u2010extract chewing gum may reduce oral malodor by decreasing the accumulation of tongue coating.\n                  <\/jats:p>","DOI":"10.1902\/jop.2010.100249","type":"journal-article","created":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T12:49:25Z","timestamp":1277988565000},"page":"1564-1571","source":"Crossref","is-referenced-by-count":39,"title":["Effect of Eucalyptus\u2010Extract Chewing Gum on Oral Malodor: A Double\u2010Masked, Randomized 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