{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T06:42:49Z","timestamp":1775025769958,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The relationship between periodontal disease and systemic disease is revealing new and exciting associations. Idiopathic edema presents a clinical syndrome with obscure pathophysiology. The present study investigates whether non\u2010surgical periodontal therapy is beneficial in patients who are not responding to conventional treatment of idiopathic edema.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Thirty patients with idiopathic edema were allocated to intervention and control groups. All the subjects were assessed for systemic (body weight, body mass index, visual scale of edema, serum C\u2010reactive protein, and serum albumin) and periodontal (plaque index, calculus index, and gingival index) parameters. Non\u2010surgical periodontal therapy, including oral hygiene instructions, scaling and root planing, and systemic antibiotic therapy, was provided in the intervention group. Both groups were reevaluated after 4 weeks.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Both groups were comparable at baseline. All parameters, except serum albumin, showed significant improvement after periodontal therapy. The control group showed further worsening of these parameters.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> This study shows that sources for systemic inflammation, such as periodontal disease, could affect the pathogenesis of idiopathic edema. Successful elimination of such covert sources of inflammation leads to a clinical benefit in patients who are distressed by this condition.<\/jats:p>","DOI":"10.1902\/jop.2010.100258","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T13:00:17Z","timestamp":1280840417000},"page":"201-209","source":"Crossref","is-referenced-by-count":8,"title":["Non\u2010Surgical Periodontal Therapy Improves Serum Levels of C\u2010Reactive Protein and Edematous States in Female Patients With Idiopathic 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