{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T15:57:52Z","timestamp":1772726272576,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this study is to evaluate levels of platelet\u2010derived growth factor\u2010BB (PDGF\u2010BB) in gingival crevicular fluid (GCF) during the early stages of healing for sites treated by marginal periosteal pedicle (MPP) graft as an autogenous guided tissue membrane compared to that of the control open flap debridement (OFD).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Fifteen non\u2010smoking patients (13 males and 2 females) with severe chronic periodontitis participated in this prospective, controlled, masked trial. Each subject contributed matched pairs of 2\u2010 or 3\u2010walled intrabony interproximal defects in premolar or molar teeth. Interproximal contralateral defects were randomly assigned to either the MPP group 1 or control OFD group 2. GCF samples were collected at 1, 3, 7, 14, and 30 days after surgery. PDGF\u2010BB in the GCF samples was measured using a human PDGF\u2010BB enzyme\u2010linked immunosorbent assay kit.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> In both MPP and OFD, PDGF\u2010BB concentrations peaked in the samples obtained during the early postoperative days (days 2 and 3) and decreased sharply in the samples obtained 7, 14, and 30 days post\u2010surgery.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Periosteal coverage of periodontal defects is not associated with a significant increase in PDGF\u2010BB levels.<\/jats:p>","DOI":"10.1902\/jop.2010.100277","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T13:00:17Z","timestamp":1280840417000},"page":"272-280","source":"Crossref","is-referenced-by-count":13,"title":["Platelet\u2010Derived Growth Factor\u2010BB Release Profile in Gingival Crevicular Fluid After Use of Marginal Periosteal Pedicle Graft as an Autogenous Guided Tissue Membrane to Treat Localized Intrabony 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