{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T22:09:33Z","timestamp":1774390173678,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this study is to evaluate the long\u2010term benefits of regenerative therapy and which factors (i.e., smoking, oral hygiene, radiographic angle, tooth, clinical center, and biomaterial) influence results.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A total of 120 infrabony defects were treated with guided tissue regeneration using bioabsorbable and non\u2010resorbable membranes with grafts or enamel matrix derivative (EMD) proteins. At baseline, smoking, x\u2010ray angle, probing depth (PD), recession, and clinical attachment level (CAL) were recorded. CAL was measured 1 year post\u2010surgery and every 2 years for \u226416 years. The participation of patients in oral hygiene protocols was recorded.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The mean \u00b1 SD baseline CAL was 8.5 \u00b1 2.3 mm, baseline PD was 7.8 \u00b1 2.1 mm, and baseline x\u2010ray angle was 31.8\u00b0 \u00b1 8.9\u00b0. One year post\u2010surgery, CAL gain was 4.1 \u00b1 2.1 mm. EMD was used in 47 defects, bioabsorbable membranes with deproteinized bovine bone were used in 41 cases, non\u2010resorbable membranes were used in seven defects, bioabsorbable membranes and autogenous bone were used in five defects, and a combination was used in 20 defects. A total of 10% of subjects were smokers, and 20% of subjects did not participate in an oral hygiene program. The average follow\u2010up was 9 years. A total of 90% teeth survival was achieved at 13 years, and CAL gain was maintained at 82% for 11 years. Statistical analyses demonstrated that smoking and oral hygiene maintenance influenced long\u2010term outcomes. The x\u2010ray angle, tooth, clinical center, and biomaterials did not influence results.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Regenerative therapy provided a high percentage of long\u2010term success. Smoking and non\u2010participation in oral hygiene maintenance negatively influenced the prognosis, whereas other factors did not affect long\u2010term results.<\/jats:p>","DOI":"10.1902\/jop.2010.100297","type":"journal-article","created":{"date-parts":[[2010,11,16]],"date-time":"2010-11-16T10:33:17Z","timestamp":1289903597000},"page":"668-675","source":"Crossref","is-referenced-by-count":43,"title":["120 Infrabony Defects Treated With Regenerative Therapy: Long\u2010Term Results"],"prefix":"10.1002","volume":"82","author":[{"given":"Maurizio","family":"Silvestri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Rasperini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Milani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1993.tb00202.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1993.tb00204.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1982.tb02095.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb00854.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00247.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.00690.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508400605"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.3.217"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1997.00833.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00562.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027008603.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.1.25"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s3.7.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.5.726"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.10146.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.1.3"},{"key":"e_1_2_7_18_1","first-page":"121","article-title":"Long\u2010term clinical observation of treatment of infrabony defects with enamel matrix derivative (Emdogain): Surgical reentry","volume":"25","author":"Rasperini G","year":"2005","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01265.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01499.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01263.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01295.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.5.672"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070571"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.77.1.88"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.1.38"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1985.56.4.204"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.4.261"},{"key":"e_1_2_7_29_1","first-page":"589","article-title":"The simplified papilla preservation flap. 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