{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T21:38:44Z","timestamp":1766180324308,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this randomized, split\u2010mouth, single\u2010masked study is to compare the efficacy of a gel and microspheres as drug\u2010delivery systems in the treatment of periodontal disease.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Microspheres were prepared, the release patterns of the microspheres and gel formulations were analyzed using an ultraviolet spectrophotometer, and particle shapes were studied under a scanning electron microscope. A split\u2010mouth design was followed in which 30 potential sites were identified and divided into three groups: one control group and two groups in which microspheres or a gel was placed. Patients were recalled at 1, 3, 6, and 9 months. Clinical recordings included plaque index (PI), gingival index (GI), probing depth (PD), and relative attachment level (RAL) measurements; subgingival plaque was also obtained for microbiologic examination prior to and after therapy.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Microspheres had a more sustained release and a high initial drug concentration. There was a significant improvement in the PI and GI in the initial 3 months. The results were statistically significant at <jats:italic>P<\/jats:italic> = 0.01. The mean PD scores among scores for the three groups at baseline and follow\u2010up visits showed a reduction of 0.4 to 1 mm. The microbiologic parameters were also statistically significant.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> These data suggest that the type of delivery system could significantly influence the outcome of therapy.<\/jats:p>","DOI":"10.1902\/jop.2010.100324","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T13:00:17Z","timestamp":1280840417000},"page":"114-121","source":"Crossref","is-referenced-by-count":21,"title":["Randomized, Controlled, Single\u2010Masked, Clinical Study to Compare and Evaluate the Efficacy of Microspheres and Gel in Periodontal Pocket Therapy"],"prefix":"10.1002","volume":"82","author":[{"given":"S.","family":"Srirangarajan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghavendra 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