{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:54:30Z","timestamp":1762505670841,"version":"build-2065373602"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> It has become increasingly clear in recent years that periodontal disease can cause a dramatic increase in the levels of markers of systemic inflammation, and that periodontal treatment can result in reduction in the levels of these markers. We have previously shown that the prevalence of moderate to severe periodontitis was significantly higher in patients with familial Mediterranean fever (FMF) with amyloidosis than in patients with FMF without amyloidosis. Thus, the aim of this study is to investigate if chronic periodontitis is associated with secondary amyloidosis in the Black Sea region of Turkey.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A total of 112 patients with biopsy\u2010proven secondary amyloidosis (59 patients with FMF, 40 patients who were either chronically infected or had malignant disease, 13 patients with periodontitis) and 22 healthy subjects, were included in this study. Periodontal health and disease were evaluated using gingival index (GI), papillary bleeding index (PBI), plaque index (PI), and periodontal disease index (PDI). The concentrations of serum acute phase reactants (APRs) were measured at baseline and at 4 to 6 weeks after completion of the non\u2010surgical periodontal therapy.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The prevalence of moderate to severe periodontitis was 47.5% in patients with FMF, 72.5% in patients who were either chronically infected or had malignant disease, and 84.6% in patients with periodontitis. Serum levels of APRs in patients with amyloidosis were reduced significantly after non\u2010surgical periodontal therapy (<jats:italic>P<\/jats:italic> &lt;0.01).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Periodontitis can increase the levels of APRs and potentiate the development of amyloidosis either by themselves or association with traditional factors, such as FMF and other chronic inflammatory diseases. Thus, preventing or treating periodontitis might prevent or at least alleviate the progression of amyloidosis. Periodontal evaluation should be performed as part of a medical assessment and considered as an etiologic factor for secondary amyloidosis.<\/jats:p>","DOI":"10.1902\/jop.2010.100439","type":"journal-article","created":{"date-parts":[[2010,11,2]],"date-time":"2010-11-02T14:41:10Z","timestamp":1288708870000},"page":"566-574","source":"Crossref","is-referenced-by-count":5,"title":["Interaction Between Periodontal Disease and Systemic Secondary Amyloidosis: From Inflammation to Amyloidosis"],"prefix":"10.1002","volume":"82","author":[{"given":"Murat \u0130nan\u00e7","family":"Cengiz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naz\u0131r","family":"Yayla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuddusi","family":"Cengiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Bagci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emre","family":"Ta\u015fk\u0131n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-134981"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.57.121304.131243"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070265"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-006-0265-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408183310701"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060499"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345000790010701"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01530.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl604"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2001.00011.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.7.1007"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300214"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508400312"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1179\/acb.2005.021"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000124"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-001-0582-9"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(67)90167-2"},{"key":"e_1_2_7_20_1","first-page":"479","article-title":"On the formation and disappearance of amyloid in man","volume":"63","author":"Waldenstr\u00f6m H","year":"1928","journal-title":"Acta Chir Second"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.77.913.686"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007152320216"},{"key":"e_1_2_7_23_1","first-page":"425","article-title":"Systemic inflammation in cardiovascular and periodontal disease: Comparative study","volume":"9","author":"Glurich I","year":"2002","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2008.01115.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2004.0250"},{"key":"e_1_2_7_26_1","first-page":"106","article-title":"MEFV mutations in patients with familial Mediterranean fever in the Black Sea region of Turkey: Samsun experience [corrected]","volume":"35","author":"Yigit S","year":"2008","journal-title":"J Rheumatol"},{"key":"e_1_2_7_27_1","unstructured":"World Health Organization Oral Health Surveys.Basic methods.Geneva:WHO Oral Health Country\/Area profile program1997. 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