{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T05:14:20Z","timestamp":1770700460918,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Data concerning treatment outcomes in patients with generalized aggressive periodontitis (GAgP) are limited. The aim of this study is to investigate 6\u2010month clinical and microbiologic outcomes of the one\u2010stage full\u2010mouth disinfection (OSFMD) in the management of patients with GAgP.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty\u2010seven patients with advanced GAgP were included in this prospective follow\u2010up intervention study. Clinical and microbiologic parameters were collected at baseline and 3 and 6 months after the OSFMD. Patient\u2010, tooth\u2010, and site\u2010level analyses were carried out. Subgingival samples from moderate (4 to 5 mm) and deep (\u22656 mm) pocket sites were analyzed using a polymerase chain reaction for <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> (previously <jats:italic>Actinobacillus actinomycetemcomitans<\/jats:italic>), <jats:italic>Prevotella intermedia<\/jats:italic>, <jats:italic>Porphyromonas gingivalis<\/jats:italic>, <jats:italic>Tannerella forsythia<\/jats:italic> (previously <jats:italic>T. forsythensis<\/jats:italic>), and <jats:italic>Treponema denticola<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The OSFMD resulted in significant improvements in all parameters. After 6 months, the whole\u2010mouth probing depth (PD) decreased from 4.2 \u00b1 1.1 mm to 2.8 \u00b1 0.6 mm, and the clinical attachment level was reduced from 4.5 \u00b1 1.2 mm to 3.4 \u00b1 1.1 mm (<jats:italic>P<\/jats:italic> &lt;0.001). When data were analyzed based on the frequency distribution of PD, the number of sites with PD \u22655 mm decreased by 61% from baseline values, and mean PD reductions of 1.5 and 2.5 mm were noted in moderate and deep pockets, respectively. At 6 months, percentages of moderate and deep sites free of pathogens were 40% and 27%, respectively.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The OSFMD may be a viable approach to deal with severe GAgP.<\/jats:p>","DOI":"10.1902\/jop.2010.100468","type":"journal-article","created":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T16:26:47Z","timestamp":1290529607000},"page":"845-853","source":"Crossref","is-referenced-by-count":20,"title":["One\u2010Stage Full\u2010Mouth Disinfection as a Therapeutic Approach for Generalized Aggressive 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